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Article Review/Hyperlink |
Stegeman CA, Tervaert JWC, de Jong PE, Kallenberg CGM for the Dutch Co-trimoxazole Study Group
Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses in Wegener's Granulomatosis
N Engl J Med (Jul) 335:16-20 1996
When DeRemee first reported marked improvement in a patient with Wegener's granulomatosis when treated with trimethoprim-sulfamethoxazole, I am sure many people chuckled. The paper by Stegeman suggests that there is something here that can no longer be dismissed. Whether the drug is acting in an antimicrobial or non-specific capacity, of course, cannot be determined. (jtd)
The abstract of this paper is available from the National Library of Medicine's PubMed site: click here .
For accompanying editorial by DeRemee: Click here.
