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Article Review/Hyperlink |
Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP et al
Small peptides as potent mimetics of the protein hormone erythropoietin
Science (Jul) 273:458-463 1996
This is a basic science paper which holds out hope for a cheaper alternative to synthetic EPO to treat anemia in ESRD. Small peptides were developed in the laboratory which bound to and activated the EPO receptor. The signalling pathways activated by the peptides seemed to be identical to that of native EPO. They had no sequence homology with native EPO.
Comment: This important discovery holds new promise for many new EPO-mimetic drugs, including perhaps eventually, an orally acting agent. Buy stock in these companies! (John T. Daugirdas, M.D., University of Illinois at Chicago)
The abstract for this article is available from the AAAS: Click here.
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