HDCN Article Review/Hyperlink

Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM

Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis

Ann Int Med (Dec) 125:961-968 1996

Long term use of corticosteroids can lead to bone loss and higher risk of vertebral fracture. Buckely et al show that in patients receiving low dose steroids (average 5 mg/day prednisone), bone density decreased in the lumbar spine and trochanter at a rate of 2% per year, but actually increased if calcium supplementation and vitamin D3 were given concomitantly.

The full text of this paper is available from the American College of Physicians at this site .