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Article Review/Hyperlink
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Fliser D, Franek E, Fode P, Stefanski A, Schmitt CP, Lyons M,
Ritz E
Subacute infusion of physiologic doses of parathyroid hormone
raises blood pressure in humans
Nephrol Dial Transplant
(May) 12:933-938 1997

Hypertension is common in hyperparathyroidism.
Iseki, Massry, and Campese
noted that PTH had a permissive role in the hypertension
associated with hypercalcemia.
Peter Pang and colleagues
have suggested the existence in SHR rats of a parathyroid
hypertensive
factor, distinct from PTH, although it's specific structure remains to be
identified.
How hyperparathyroidism might cause hypertension is otherwise unknown, as PTH
has a
hypotensive effect when injected into animals. In this paper, Fliser et al
inject
"physiologic" doses of 1,34-PTH into normal non-uremic humans, and found
increases in
serum calcium, platelet calcium, and MAP. The increases in MAP correlated
with
increases in platelet calcium levels. The increase in MAP were tiny (84 to
88 mm
Hg), but they did correlate with changes in platelet calcium levels. Whether
PTH
has a role in the hypertension of uremia remains unknown.
The abstract of this paper is available from Oxford Press
at
this site.
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