Wardlaw JM, Warlow CP, Counsell C
Systematic review of evidence on thrombolytic therapy for acute
ischaemic stroke
Lancet
(Aug) 350:607-614 1997

Because of a
single trial
showing that early administration of tissue plasminogen activator may be
beneficial in
acute stroke the US FDA approved t-PA for this indication. However, the
present review
takes a more sober view, and points out that the benefits of t-PA are not
clearcut, that
the risk of hemorrhage is indeed increased, that the risk of bleeding may be
very high
with concomitant aspirin ingestion (and many such patients will be taking
aspirin), and
that most typical patients will not be eligible for such therapy.
The abstract of this paper is available from the National Library of
Medicine's PubMed
site:
click here .