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Article Review/Hyperlink
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Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM,
Raghunathan TE, Vos HL
A common prothrombin variant (20210 G to A) increases the risk
of myocardial infarction in young women
Blood
(Sep) 90:1747-1750 1997

Rosendaal and colleagues have published 3 papers in the last 6 months
identifying three
heretofore unknown risk factors for myocardial infarction in young women. In
this paper, they find that a factor II (prothrombin) variant (20210 G
to A) was
associated with an odds ratio of 4.0. In a previous paper in
April in Blood, they found a slightly weaker association
(odds ratio =
2.4) with the Factor V Leiden mutation. Finally, in
the July issue of Circulation , they found an odds ratio
of about 2.0
associated with plasma total homocysteine levels greater than 15.6 µM.
So risk of
MI becomes a more interesting story than just smoking, hypertension, and
cholesterol.
(Daugirdas)
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