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Article Review/Hyperlink
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Wolf G, Ziyadeh FN, Thaiss F, Tomaszewski J, Caron RJ, et al
Angiotensin II stimulates expression of the chemokine RANTES in
rat glomerular endothelial cells
J Clin Invest
(Sep) 100:1047-1058 1997

Chemokines are believed to be important in causing glomerular injury, as they
serve
to attract macrophages and monocytes to injured tissues. In this paper, in
cultured
glomerular endothelial cells, ANG II was found to stimulate production of one
chemokine
called RANTES, and this effect was found
to be mediated via AT2 receptors. AT1 blockers such as
losartan potentially cause indirect stimulation of AT2 receptors, as they
result in a reflex
increase in circulating levels of angiotensin. The findings of this study
thus imply that drugs
such
as losartan may be less efficacious than ACE-inhibitors in preventing certain
forms of
renal injury.
(John T. Daugirdas, M.D., University of Illinois at Chicago)
The full text of this article is available from the
JCI online site at
this link
.
The abstract of this paper is available from the National Library of
Medicine's PubMed site:
click here .
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