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Article Review/Hyperlink |
Brodsky RA, Petri M, Smith BD, Seifter EJ, Spivak JL, et al
Immunoablative high dose cyclophosphamide without stem cell rescue for refractory, severe autoimmune disease
Ann Intern Med (Dec) 129:1031-1035 1998
Eight patients with severe, refractory, autoimmune disease, among them two with lupus, received high dose cyclophosphamide (50 mg/kd/day) for 4 days, without stem cell rescue, followed by granulocyte-colony stimulating factor. One woman with membranous lupus had "continuous complete remission 12 months after treatment", with resolution of anti-DNA antibodies and a 24-hr urinary protein excretion of only 86 mg. Taking only 1 mg/day of prednisone. Another case of lupus with antiphospholipid syndrome is described as being in partial remission, with reduction of prednisone dose to 5 mg qod. In total, five of the 8 patients treated for a variety of disease are reported to be in complete remission. (John T. Daugirdas, M.D., University of Illinois at Chicago)
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