Rault R, Magnone M
The effect of parathyroidectomy on hematocrit and
erythropoieting dose in patients receiving hemodialysis
42nd Annual Conference of the ASAIO
ASAIO J
(May) 42:(2):74 1996
The authors report the changes in hematocrit and erythropoietin dose
after parathyroidectomy in
10 patients, comparing 1 month pre-op values to those obtained
1 and 6 months post-operatively.
Six months after parathyroidectomy, mean hematocrit rose from
28.9 to 33.3%, while the mean EPO dose fell from
9100 to 4700 U/wk (P < 0.01
for both by paired t-test). PTH values are not reported, except to note
that they fell from a mean of 15 times normal to 2.3 times normal.
Comment: Much is left out here, and the statistics are shaky
(paired t-test
instead of the more appropriate repeated measures ANOVA), but the data
are suggestive and plausible. Most interesting is the long time
apparently necessary for an effect of parathyroidectomy on hematocrit
to manifest, consistent with
relatively slow resolution of marrow fibrosis. More time points would
be useful; it has been my impression that improvement in hematocrit after
parathyroidectomy may continue for well more than a year.
(Robert H. Barth, M.D., VA Medical Center, Brooklyn, NY)
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42nd Annual Conference of the ASAIO
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