Zabetakis PM, Dasgupta MK, Cotell CM
Hydroxyapatite-coated silastic peritoneal dialysis catheter
implants in rabbits induce a greater degre of pericatheter tissue
healing than uncoated silastic catheters
43rd Annual ASAIO Conference, Atlanta
ASAIO J
(Apr) 43:79 1997
This is an interesting approach to the unrelenting problem of PD
peritonitis and, especially, tunnel infections. A thin layer of
hydroxyapatite on the catheter seems to induce a more vigorous reaction
in the surrounding tissue, resulting in better healing and
vascularization of the tunnel. This sounds like a promising idea.
Presumably the coating can be limited to the intra-abdominal wall
portion of the catheter, since a vigorous fibrotic reaction might not be
terribly desirable within the peritoneal cavity.
This abstract brings up an interesting semantic question, with its use
of the term "biocompatibility". What do we mean by this? One might
think that this material was being demonstrated to be rather
bio*IN*compatible; that is, inductive of an more vigorous tissue
reaction. In this case, biocompatibility, if we define it as
unreactivity with biological systems, seems actually to be an
undesirable thing.
(Robert H. Barth, M.D., VA Medical Center, Brooklyn, NY)
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43rd Annual ASAIO Conference, Atlanta
Basic peritoneal dialysis :
PD catheters