Akiba T, Ota F, Fushimi K, Tamura H, Hata T, Marumo F
Water channel AQP1, 3, 4 in the human peritoneum and peritoneal
dialysate
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S5 1997
To clarify the mechanism of osmotic gradient driven water transport through
"ultra small pores" the authors tried to identify water channels in the
peritoneum and in cells recovered from peritoneal dialysate. Peritoneal
membrane
samples were obtained by surgical excision from uremic patients at time or
insertion or removal of a PD catheter. Aquaporin AQP1, AQP3, AQP4 mRNA
were searched for in dialysate sediments and peritoneal samples.
The data suggested the aquaporins are present in the peritoneum
and might participate in the water transport.
Comment: This abstract seems to confirm new recent theories
concerning
the role of aquaporins in peritoneal transport.
(Christian Verger, M.D., Pontoise, France)
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17th Annual CAPD Conference
Basic peritoneal dialysis :
Physiology