Algrim-Boyle C, Zeigler N, Ristow T, Putignano P, Vonesh E, Blazer J, Moran J
An evaluation of the causes which lead to transfer from peritoneal dialysis
17th Annual CAPD Conference
Perit Dial Int Suppl 1 (Feb) 17:S55 1997

This study from Baxter USA looks at the reasons that led to 253 patients discontinuing PD at 94 different units during March 1996. Data obtained is based on a phone survey with a PD nurse at each unit. The investigators find that 49% of the 253 patients leaving PD died, and that in over one-third of these the cause of death was cardiac, with the second commonest cause being infection in just under one-quarter of the patients. Among the 51% of patients who left PD to switch to hemodialysis, 37% were due to peritonitis, 9% to inadequate dialysis and 9% to catheter problems. The remainder were due to a variety of reasons. It was notable that the commonest causes of peritonitis leading to modality switch were fungi in 28% and multiple organisms in 15%.

The authors conclude that peritonitis remains a major cause of PD failure despite the introduction of new and better disconnect systems. It could, of course, be argued that the newer disconnect systems have led to a decrease only in the less severe forms of peritonitis such as those due to touch contamination [eg, Staph epidermidis]. It is notable that, from all the attention it receives, only 9% of patients switching to hemodialysis did so because of so-called "inadequate PD". It should, however, be pointed out that many of the 15% who switched for "other medical" reasons and that the 29% switched for "other" reasons may include cases where inadequate dialysis was a contributor to the adverse outcome. The most important point about this study, however, is that it re-emphasizes the fact that peritonitis remains a major problem in PD patients. (Peter G. Blake, M.D., Victoria Hospital, London, Ontario)

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17th Annual CAPD Conference
CRF: Problem Areas : Outcomes (Morbidity, Mortality)
Basic peritoneal dialysis : Complications of PD