Mahiout A, Jaekle-Meyer I, Matata BM, Topley N, Passlick-
Deetjen J
Relationship between glucose and calcium in the glycation of
collagen matrix when exposed to peritoneal fluids
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S7 1997
The authors have investigated the effect of glucose and calcium
concentrations in lactate buffered PD fluid on the formation of advanced
glycated end products (AGE). For this purpose an in vitro model of collagen
matrix was used where bound AGE-collagen was measured after PDF
expositlon.
A reduction of AGE-collagen was observed in solutions containing 1.56% or
2.3% glucose and 1.12 mmol/L calcium, compared to solutions containing
1.00 mmol or 1.75 mmol calcium, or in 4.25% glucose solutions whatever the
concentration of calcium.
The authors conclude that at low pH, dialysate calcium level may play an
important role in the glycation process of the peritoneum.
Comment: This is an interesting abstract which may have important
clinical
implications on the long term survival of the peritoneal membrane. However
we
have no information on the number of assays performed, nor on the
statisitical significance of the differences. In addition it seems that
only the intermediate concentration of calcium (1.25 mmol/L) has an effect
on
the reduction of AGE, as no modification is observed with the lowest
(1 mmol/L) and the highest (1.75 mmol/L) concentrations. This suggest that
there
might be be an optimal calcium concentration to miminize AGE.
(Christian Verger, M.D., Pontoise, France)
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17th Annual CAPD Conference
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