Misra M, Webb A, Reaveley DA, Doherty E, O'Donnell M, Seed M,
Brown EA
The effect of change of renal replacement therapy on plasma
lipoprotein (a) [Lp(a)] concentration
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S64 1997
There is a suspicion that atherogenesis is enhanced in PD patients vs. HD
patients. Lipoprotein a (Lpa) is an atherogenic lipid, the levels of which
are elevated in both PD and HD. Rather than a cross-sectional view of Lpa
levels, in this paper the patients' Lpa levels were followed as a function
of modality change.
In 21 patients on HD or CAPD who were transplanted, Lpa levels fell in 8
CAPD patients but remained similar in 13 HD patients. In 11 patients whose
transplants failed and who went on either HD or CAPD, Lpa levels increased
in those put on CAPD but not those who started HD. In 16 patients who were
changed from CAPD to HD, Lpa levels fell significantly.
Comment: The data show that modality affects Lpa levels, being
higher on CAPD than on HD or in transplant patients. The implication is
that CAPD patients may run an increased atherogenic risk. (John T.
Daugirdas, M.D., University of Illinois at Chicago)
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17th Annual CAPD Conference
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