Nishina M, Nomoto Y, Tanabe R, Nakao E, Endo H, Nakajima K,
Suga T, Endo M, Sakai H
The study of ACE converting enzyme polymorphism on CAPD
patients
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S65 1997
Evidence about the deleterious effects of the DD ACE genotype continues to
accumulate. In this study, ACE polymorphism genotype was evaluated in 60
CAPD patients. It was found that the rate of loss of Kru, measured as
residual urine volume, was higher in patients with the DD genotype than in
patients with the II or ID genotype. Also, the cardiothoracic ratio was
higher (53%) in patients with the DD genotype vs. about 47% in patients
with the ID or II genotype. The authors believe that their data suggest an
adverse effect of the DD genotype in CAPD patients on both heart size and
maintenance of Kru.
Comment: The measurement technology use in this study was quite
basic, with urinary volume being used to assess residual GFR and Chest X-
ray instead of echocardiography used to assess heart size. No blood
pressure data are given. This preliminary study needs to be confirmed and
extended. (John T. Daugirdas, M.D., University of Illinois at
Chicago)
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17th Annual CAPD Conference
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