Shemin D, Maaz D, Sharp B, St Pierre D, McCusker C, Seyboth V
The effect of aminoglycoside use on residual renal
function in PD patients
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S38 1997
Aminoglycoside use may impair residual renal function (RRF) in PD
patients. In this study, the effect of IP and IV antibiotics on
the decline of urinary creatinine clearance (UCC decline) was
observed in 41 patients followed for a mean of 15 months. UCC
decline was -0.20 ml/min/mo. in patients without antibiotic
treatment (N=21), -0.11 in patients treated with non-
aminoglycoside antibiotics (N=14), and -0.59 in patients treated
with aminoglycosides for %gt; 3 days (N=6) (p < 0.05). Thus
aminoglycosides may accelerate loss of RRF.
Comment: Since residual function has a major effect on the
number and volume of exchanges needed to maintain adequacy, these
findings may be clinically significant. However, the number of
patients observed is small and the study was not randomized. A
larger prospective randomized study should be performed.
(David J. Leehey, M.D., Loyola University at Chicago)
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17th Annual CAPD Conference
Basic peritoneal dialysis :
Peritonitis and exit-site infection
ARF etiology :
Other drug-associated ARF