Troidle L, Gorban-Brennan N, Kliger AS, Finkelstein FOF
2-Gram intraperitoneal cefazolin for the treatment of
peritonitis
17th Annual CAPD Conference
Perit Dial Int Suppl 1
(Feb) 17:S40 1997
With the emergence of vancomycin-resistant enterococcal (VRE)
infection, alternatives to the routine use of vancomycin in the
treatment of peritonitis have been proposed. In this study, the
efficacy of a daily 2 gm ip dose of cefazolin for 14 days was
studied. Of the 18 episodes empirically treated, the 9 episodes
in which the organism was sensitive to cefazolin (Staph species
and E. coli) were successfully treated. Once daily cefazolin for
14 days appears to be an effective regimen for peritonitis due to
cephalosporin-sensitive organisms.
Comment: A similar regimen has been recommended as an
alternative to continuous ip cefazolin dosing by the Advisory
Committee on Peritonitis Management
(Keane et al. PDI 1996; 16:
557-73).
(David J. Leehey, M.D., Loyola University at Chicago)
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17th Annual CAPD Conference
Basic peritoneal dialysis :
Peritonitis and exit-site infection