Egan BM, Hennes MMI, O'Shaugnessy IM, Stepniakowski KT,
Kissebah AH
Obesity hypertension and insulin-resistant lipolysis
AHA Council for High Blood Pressure Research
Hypertension
(Sep) 26:540 (abst) 1995
Insulin has effects on both glucose and non-esterified fatty acid (NEFA)
metabolism. Whereas other studies often assess insulin resistance by glucose
uptake. Egan et al measured resting and ambulatory blood pressures in 6 lean
normotensives, 6 normotensives with abdominal obesity, and 11 hypertensives
with abdominal obesity. They also measured resting plasma NEFA levels, and
glucose uptake as well as NEFA disposal under euglycemic hyperinsulinemic
clamp conditions. They found that resting diastolic BP correlated (r=0.72)
with NEFA flux during the clamp, and that addition of glucose uptake failed
to increase the predictive value of the regression equation.
The
results suggest that insulin resistance in hypertensive patients with
abdominal obesity extends to insulin effects on NEFA turnover.
(J. Daugirdas)
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AHA Council for High Blood Pressure Research
H: Special problems :
Obesity, Insulin Resistance