Galletti F, Annuzi G, Ferrara I, Ciardullo A, Noviello F,
Rivellese AA, Strazzullo P
Salt sensitivity in essential hypertensive is associated with
insulin sensitivity
AHA Council for High Blood Pressure Research
Hypertension
(Sep) 26:545 (abst) 1995
This study addresses the question as to whether insulin resistance in
essential hypertension is limited to the salt-sensitive subgoup. Of
56 patient screened with essential hypertension, 5 were chosen from
the highest (salt-sensitive) and 7 from the lowest (salt-resistant)
subgroups. The patients were matched for age, sex, and body mass
index. None were receiving anti-hypertensive medications and there
were no diabetics. Salt sensitivity was determined by mean blood
pressure response to a NaCl load given intravenously over 4 hours, and
NaCl depletion was affected by prescribing a low sodium (10 mmol/day)
diet plus furosemide given tid. In each patient, and oral glucose
tolerance test and euglycemic clamp studies were also
performed.
The salt-sensitive patients demonstrated lower whole body
insulin-mediated glucose uptake during the euglycemic clamp (mean 4.5
mg/kg/min) than the salt-resistant patients (mean 7.9 mg/kg/min). The
data suggest that insulin resistance is confined to the salt-sensitive
group of essential hypertensive patients, and that insulin resistance
may play a role in the genesis of salt-sensitivity.
(K. Griffin)
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AHA Council for High Blood Pressure Research
H: Pathophysiology :
Salt (sodium, chloride) sensitivity
H: Special problems :
Obesity, Insulin Resistance