Parmer RJ, Kailasam MT, Martinez JA, Wright FA, Wilson AF,
O'Connor DT
Evidence suggesting that urinary kallikrein excretion is
heritable in African American families with essential
hypertension
AHA Council for High Blood Pressure Research
Hypertension
(Sep) 26:545 (abst) 1995
The purpose of this study was to determine the heritability of urinary
kallikrein excretion in African Americans with essential hypertension.
101 subjects from 8 black and 15 white families were examined. The
principal finding of this study is that urinary kallikrein excretion rates
are
lower in members of black versus white families. Also, parent to
offspring correlations of urinary kallikrein excretion were higher in black
versus white families. Parmer et al concluded that kallikrein excretion
rates are genetically determined and may account for racial differences
in excretion rates. This is a potentially important finding since it could
have implications for the pathogenesis and management of hypertension
in certain populations. From a renal standpoint, it might be important in
explaining racial differences in the incidence rates of hypertensive
nephrosclerosis leading to end-stage renal disease in the United States.
(R. Toto)
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AHA Council for High Blood Pressure Research
H: Special problems :
Ethnic populations
H: Pathophysiology :
Genetics