Watanabe M, Oshima T, Higashi Y, Matsuura H, Kanbe M,
Kajiyama G
Dietary NaCl loading increases platelet calcium in
salt-resistant essential hypertension
AHA Council for High Blood Pressure Research
Hypertension
(Sep) 26:561 (abst) 1995
In order to determine cellular calcium handling with respect to salt
sensitivity, BP and platelet
fee intracellular calcium levels and calcium stores were evaluated on the
final day of a week on
each a low (50 mmol/day) and a high (340 mmol/day) sodium diet. A difference
in blood pressure of
more than 10 mm Hg between the two diets was required to diagnose salt-
sensitivity.
In the salt resistant group, both platelet intracellular calcium levels and
calcium stores were
increased on the high vs low sodium diet. In the salt-sensitive group,
intracellular calcium also
increased, and markedly so, but stores were unchanged.
The data suggest that a high salt diet may be associated platelet activation
(and ultimately
thrombogenic complications) via changes in platelet calcium levels and
stores, even in patients in
whom salt loading has no effect on the blood pressure.
(K. Griffin)
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AHA Council for High Blood Pressure Research
H: Pathophysiology :
Salt (sodium, chloride) sensitivity