Back to channel

HDCN News Archive -- Clinical Pharmacology
Oct23	Akebia sues CMS for denying coverage for Auryxia under Medicare Part D
Oct23	Taking antihypertensives at bedtimes lowers cardiovascular risk.
Aug14	Pretomanid, bedaquiline and linezolid combo FDA approved for resistant TB.
Aug13	SPRINT substudy shows that intensive BP control lowers rate of white matter brain lesions.
Jul02	HIV infection cured in mice using CRISPR technology.
Jul01	Low grade E. Coli urinary tract infections picked up by DNA testing of urine.
May09	Fournier gangrene of the genitals linked to SGLT2 inhibitor drugs
Apr29	Immune cell test identifies patients with chronic fatigue syndrome.
Apr06	Candida auris infections spreading rapidly across the globe.
Apr03	Rehydrating with soft drinks after exercise increases AKI injury markers
Jan24	Alzheimer disease linked to brain infection by gingivitis bacteria.
Dec11	Randomized PIVOT trial published in NEJM suggests more IV iron is better.
Dec05	Test detects presence of cancer in blood samples based on DNA methylation.
Aug02	Bacteria becoming tolerant to high concentrations of alcohol in hand sanitizers.
Apr28	CDC issues alert re warfarin coagulopathy and synthetic cannabinoids
Feb28	In ICU, Ringer's lactate also better than saline.
Feb28	Ringer's lactate causes less kidney injury than saline.
Jan11	Lp(a) in the news in the New York Times
Jan09	Inhibitors of NMMT reduce obesity by increasing fat cell metabolism.
Sep05	Hypervirulent, carbipenem-resistant Klebsiella pneumonia outbreak in China.
Aug11	NEJM: Idarucizumab effective for reversal of dabigatran effects.
Aug10	Immunotherapy may arrest damage of beta cells in type 1 diabetes.
Jun13	Can LIF be used to cure autoimmune diseases such as multiple sclerosis? and more?
Jun06	Dr. Fred Coe's Kidney Stone Guide Book - a work in progress.
Dec28	Pharmacies miss some drug interactions that are known to cause serious issues.
Oct05	FDA warns about hepatitis B reactivation with direct acting hepatitis C antivirals.
Jul28	Good Staph. in the nose makes novel peptide antibiotic that kills bad Staph.
May29	Three days of fasting every 10 days improve autoimmune diseases (in mice).
May29	Nicotinamide riboside protects mice from effects of diabetes.
May24	CRIC study shows a high urinary sodium excretion in CKD linked to higher CV risk.
May20	SPRINT shows lower than 120 BP systolic target in elderly results in improved outcomes
Apr27	Tetraspanin-7 as an antibody target for type 1 diabete
Apr13	New bacteria called Elizabethkingia affecting Midwest patients.
Mar30	AC6 gene therapy improves cardiac function in patients with heart failure.
Mar09	Desensitization procedure allows kidney transplants from any (living) donor.
Mar09	Is the FDA allowing promotion of off-label uses of drugs as free speech?
Feb29	Phage Therapy 2016 World Congress meets this June in Paris.
Feb29	When will be see phage therapy for exit site and access infections?
Feb27	Treatment of BP below 140 systolic in persons with diabetes may be counterproductive.
Feb20	New blood-based tuberculosis test shows promising results.
Feb14	Beetroot juice lowers blood pressure.
Feb14	Second salty taste receptor more fully characterized in humans.
Dec29	Myostatin antibody may prevent age-related decline in muscle mass.
Dec29	Interleukin-17A may prevent and even reverse diabetic kidney injury.
Dec26	Antibiotic-resistant bacteria frequency increases in U.S. streams and rivers
Dec26	FGF21 suppresses cravings for sweets.
Dec21	Ergocalciferol supplementation does not affect ESA dose in dialysis patients.
Dec14	Even more news on the new HDCN Facebook page!
Dec14	A bright future is predicted for renal denervation devices.
Dec14	Primary aldo screening for resistant hypertension cost effective?
Dec14	Some drugs cause weight gain by alterations in the gut microbiome.
Dec12	Suicide gene therapy for prostate cancer
Dec01	SecA inhibitors particularly effective against MRSA and other bacteria.
Nov30	Multinucleated giant cells and amyloidosis
Nov21	Orphan drug designation may lead to high drug prices, like for rituximab.
Nov10	STHLM3 test for prostate cancer will be in Sweden by March of 2016.
Nov10	L-DOPA may delay onset of age-related macular degeneration by 8 years.
Nov10	Sprint Blood Pressure Trial article link at NEJM
Nov10	Sprint study presented at the AHA Scientific Sessions and published in NEJM.
Sep25	Giving BP meds at bedtime particularly effective in lowering diabetes risk
Sep17	Empagliflozin use in diabetes associated with large reduction in CV risk.
Sep11	SPRINT RCT data support an even lower BP target (120 systolic) for the elderly.
Sep04	Hedge fund quant proposes a disease-specific false-positive rate to FDA for drug approval.
Aug31	Spanish style mid-day "siestas" linked to lower blood pressure and better heart structure.
Aug31	Fimrenone, a selective MRA antagonist from Bayer shows promising heart failure effects.
Aug27	FDA approves 2nd PCSK9 inhibitor, Repatha, to lower LDL cholesterol
Aug22	Packaging medications together by date to be taken and time of day.
Aug03	New artificial blood vessel coating makes them resistant to thrombosis.
Jul08	Valsartan combined with sacubitril (neprilysin inhibitor) improves heart failure patient survival.
Jul08	153 lab tests for under $10 from a finger prick test done at a local drugstore.
May23	Leptin sensitizer extracted from Chinese Thunder God vine effective in obese mice.
May20	Paired bacteriophage therapy holds promise against superbugs
May08	Putting the brakes on bacterial resistance to antibiotics with targeted antibiotic scheduling.
May07	Pioglitazone to massage mitochondria may help delay Alzheimer's disease
Apr23	Long coding RNA found that regulates brown fat production
Apr23	Currently approved antihelminthic drug effective against MRSA
Apr21	Subcutaneous islet cell transplantation holds promise
Mar31	Medieval garlic and bile potion disrupts MRSA biofilms
Feb26	Dabigatran has higher bleeding risk than warfarin in dialysis patients
Feb25	The concept of minimizing regret in poker: an application for medical treatment?
Feb20	Bourbon virus - a previously unknown Thogotovirus, associated with AKI after tick bite.
Feb12	Rapamycin in bloomberg.com as an anti-ageing drug.
Feb05	BMJ study: Intensify BP treament when SBP > 150, but do it promptly.
Jan24	FDA committee recommends approval of drug to treat invasive aspergillosis.
Jan09	New variant of aminoglycosides does not impair hearing.
Jan09	Monthly dose of PCSK9 inhibitor lowers serum cholesterol
Dec19	Ibuprofen extends lifespan in yeast., worms, and fruit flies.
Nov17	JAMA: New hyperkalemia sorbent effective in reducing hyperkalemia
Oct12	Harvard scientists produce insulin-producing pancreatic beta cells on a large scale.
Sep01	PCSK9 inhibitor arilocumab lowers cholesterol and cardiovascular events
Aug30	Novel heart failure drug shows great promise.
Aug01	Carbapenem-resistant enterobacter becoming more prevalent.
Jul16	New concerns about the safety of niacin.
Jul14	Bacteria found in healthy bladders differ from those in women with incontinence.
Jul14	Hydrogen sulfide generating compound protects stressed mitochondria.
Jul14	Phase 1 trial launched of antibiotic that targets C. difficile.
May21	ZS Pharma presenting data on it's GI potassium sorbent in patients taking RAAS inhibitors at ASH
May18	Urine fibrinopeptide B can be used to detect venous thromboembolism.
May18	Difficult-to-detect bacteria in urine associated with overactive bladder symptoms.
May18	Kallikrein inhibitor ecallantide shows some benefit in ACEI-associated angioedema.
May18	T cells targeting CS1 kill myeloma cells in animals.
May18	Aspirin retards wound healing
May13	Health benefits of resveratrol via red wine called into question by study from Italy
May07	FDA and the Heart Association and other agencies fight over aspirin
Apr22	Have we found the cure for atherosclerosis? D-PDMP a potential candidate.
Apr22	Vancomycin-resistant MRSA identified in a patient in Brazil.
Apr15	NEJM - New drug regimen cures 90% of patients with hepatitis C and cirrhosis.
Mar29	Negative SYMPLICITY HTN-3 trial results published in NEJM
Mar29	SYMPLICITY HTN - 3: Renal artery fails for resistant hypertension
Mar29	Prophylactic rosuvastatin lowers risk of contrast kidney injury.
Mar29	New class of anticholesterol drugs lowers LDL by 50%
Mar17	Large meta-analysis exonerates saturated fat in terms of elevated CV risk.
Mar13	Oxadiazoles make up a new class of antibiotics effective against MRSA.
Mar13	ITPA gene variants markedly affect risk of recurrence of hepatitis C after treatment.
Mar13	Some NSAIDs found to have weak antibacterial activity.
Mar02	Rare gene deletion that protects the obses against type 2 diabetes identified.
Feb28	Beta-blockade found to benefit ESRD patient survival and CV risk
Feb24	New form of pneumococcal vaccine (Prevnar 13) protects elderly adults.
Jan17	Google's smart contact lens project to be piloted to monitor blood sugar levels.
Jan14	New device informs treatment of sleep apnea.
Jan14	Potential rewrite of human research guidelines will facilitate database studies.
Jan14	ZS Pharma announces positive results from extended treatment results of hyperkalemia drug.
Dec23	Staph stopper vaccine developed at U. Iowa
Dec14	Long-term use of proton-pump inhibitors linked to vitamin B12 deficiency.
Nov25	FDA removes certain restrictions from Avandia.
Nov19	Gene therapy shows long-lasting benefits in patients with heart failure.
Nov19	Aldehyde compound stimulates UC-1 to burn body fat.
Nov19	Low-dose dopamine or nesiritide of no help in acute heart failure.
Nov19	Eveolocumab lowers LDL cholesterol in patients with marked hypercholesterolemia.
Nov18	Abatacept slows or halts proteinuria in FSGS.
Nov18	VA NEPHRON D Sttudy in NEJM: Combination ACE-I and ARB treatment for diabetic nephropathy with proteinuria found to be harmful.
Nov05	Sofosbuvir, simeprevir, and ledipasvir combos may cure hepatitis C infection.
Nov04	Many herbal supplements do not contain what's on the label.
Nov01	New oral sorbent targeting hyperkalemia; trial results to be presented at ASN.
Oct27	New K-absorbing compound prevents hyperkalemia with spironolactone.
Oct20	207 nm UV light may be useful to prevent surgical wound infections.
Oct20	Bacteriophages targeting C. difficile: magic bullets against superbugs?
Oct13	Master regulators control gene expression and may affect disease susceptibility.
Oct13	Body uses RNA interference to combat viral infections.
Oct13	Recombinant Human Prion Protein Inhibits Prion Propagation
Sep25	Melatonin stimulates brown fat formation.
Sep18	A mechanism to kill tuberculosis bacteria has been discovered.
Sep18	Arginine therapy may be useful to treat sickle cell disease related pain.
Sep02	Study of saxagliptin for diabetes shows no increase in heart attack risk.
Aug07	Long-term use of calcium channel blockers linked to increased breast cancer risk.
Aug07	New approach to treat diseases with inherited mutations of mitochondrial DNA.
Aug07	Are we smarter than a 10-year old? Quantitative biology yields new insights into bacterial metabolism.
Jul13	Modified HIV vector used to cure 2 genetic disease in children.
Jul11	Rare mutation triggers race to develop new cholesterol drugs.
Jul05	Salsalate lowers blood glucose in type 2 diabetes.
Jul05	Brown fat activation may be responsible for accelerated atherosclerosis in winter.
Jul05	DHA (in fish oil) reduces inflammation via maresin in macrophages.
Jul05	Blocking CD36 might affect inflammation-induced atherosclerosis
Jun21	Silver found to have marked antibacterial properties when added in small amounts to antibiotics.
Apr07	Vitamin D deficiency impedes mitochondrial energy metabolism in muscle.
Apr05	Hepatitis A virus has a cloaking device made from the infected host cell membrane.
Apr05	Malic acid mouth spay for xerostomia.
Mar20	High potency statins increase risk of acute kidney injury (slightly).
Mar17	Macrophages found to play key role in regulating red blood cell levels.
Mar17	Cholecalciferol treatmen of African Americans with hypertension good.
Mar17	Hospital epidemiology study suggests that 1/3 of antimicrobial drug prescriptions in dialysis patients are inappropriate.
Mar17	Fluoroquinolone-resistant E. Coli strains becoming more common in elderly adults.
Mar17	Darbepoietin treatment does not improve survival in anemic heart failure patients.
Mar09	Niacin drug plus antiflushing compound had substantial side effects.
Mar08	New study validates anti-aging effects of resveratrol.
Mar07	High salt diet linked to activation of Th-17 helper cells and multiple sclerosis in mice.
Feb16	Synthetic marijuana linked to acute interstitial nephritis.
Feb16	Dogs cured of type 1 diabetes by gene therapy.
Feb16	Cure for Chagas disease found?
Feb16	Are mycotoxin progenitor molecules found in grains responsible for kidney toxicity?
Feb16	Another study shows increased cardiovascular risk in women with high calcium intake.
Feb16	ADAMTS7, thrombospondin, genetics, and arterial plaque.
Feb16	Off-patent generic drug amlexanox may beneficially affect diabetes.
Feb16	New metabolic pathway identified in Staph bacteria as a target for novel antibiotics.
Feb16	Vitamin D potency varies widely in nonprescription supplements.
Jan21	Regular aspirin use associated with risk of age-related neovascular macular degeneration.
Jan10	DaVita announces drug supply agreement with Fresenius Medical Care.
Jan10	Gene therapy reprograms scar tissue in damaged hearts.
Dec16	Anti-HIV drug protects leukoctyes against Staph. aureus infection.
Dec13	Endothelin antagonist sitaxentan good for CKD with heart disease.
Dec07	FDA issues new labeling requirements for heparin vials.
Dec06	Microbial stowaways in antiseptic products
Dec06	Beta-hydroxybutyrate, histone deacetylase, calorie restriction, and slower aging.
Dec06	Aspirin tablet coatings may give rise to aspirin pseudoresistance.
Dec01	Single-treatment gene therapy targeting telomerase extends lifespan of mouse by 24%.
Nov26	Genes controlling cortisol and aldosterone found to be implicated in human hypertension.
Nov19	Nanotechnology cures multiple sclerosis in mice; are other autoimmune diseases next?
Nov10	Loss of essential blood gene (Atpif1) leads to anemia.
Nov10	Trio of new drugs from Abbott shows high cure rate for hepatitis C.
Nov05	Cinacalcet for hyperparathyroidism trial results published in NEJM.
Nov05	Nabilone shows benefits in managing pain of diabetic neuropathy.
Nov05	Eculizumab for atypical HUS shows promise on longer term treatment.
Nov05	Tolvaptan study shows promising results in polycystic kidney disease.
Oct25	Using human stool to treat C. difficile colon infestations is safe and effective.
Oct19	Bardoxolone study terminated by safety monitoring committee.
Oct17	Cranberry juice unlikely to help in cystitis.
Oct10	Drs. Lefkowitz and Kobilka share chemistry Nobel prize for discovery of G-protein coupled receptors.
Oct09	Neuroprotectant drug effective in maintaining brain function after aneurysm surgery.
Oct09	New class of antimicrobial drugs active against Staph aureus discovered.
Oct02	Increasing levels of FGF2 tied to age-related muscle wasting; reversed with an inhibitory drug.
Oct02	100K units of vitamin D per month does not reduce incidence of colds.
Sep25	Lithium may not work in some patients; and these failures can be detect by lack of gene induction.
Sep25	Bacteriophages targeting Pseudomonas may be used to destroy biofilm.
Sep19	Cost-effectivenes study of renal sympathetic denervation published.
Sep19	Compound found in purple corn reduces macrophage activation in diabetic nephropathy in mice.
Sep12	Fish oil supplement meta-analysis in the news (found no benefit)
Sep12	Serious adverse effects of fluoroquinolones in the news.
Sep07	Nonalcoholic red wine reduced blood pressure better than regular red wine.
Sep07	CKD patients have reduced ability to prevent vascular calcification.
Sep07	Researchers decipher manic gene.
Sep05	Junk DNA turns out to play a major role in cell regulation.
Aug27	Niacin may help the body fight against Staph. aureus infection. via CEBPE gene.
Aug16	CD4 T cells linked to immunologically-mediated atherosclerosis; vaccine may be possible.
Aug16	(+)-naloxone blocks opioid addiction by an immunologic mechanism.
Aug16	Obatoclax and flavopiridol for multiple myeloma.
Aug09	CDC online course in infection prevention in dialysis units.
Aug09	Do neutrophils mediate insulin resistance in obesity?
Aug03	Diacetyl, an artificial butter flavor used in popcorn, linked to Alzheimer's disease worsening.
Aug02	KDIGO releases new, 2012 version of anemia guidelines; 9.0 g/dL Hb is the new lower bound.
Jul21	FDA: Seizure risk from cefepime in patients with renal impairment.
Jul18	FDA approves second diet drug within a month.
Jul12	Circadian clock cryptochromes tied to development of type 2 diabetes.
Jul12	Cucurmin reduces incidence of type 2 diabetes in randomized control trial.
Jul10	FDA approves viral load test for patients with CMV infection.
Jul05	Metformin may boost brain function via stimulation of new neuron formation.
Jul05	Fracture benefits of vitamin D in the elderly appear only at doses greater than 800 IU / day.
Jun28	Favorable early results after renal denervation in CKD.
Jun28	FDA approves new weight loss drug lorcaserin (Belviq)
Jun27	Considerable variability found between 25-D assays.
Jun23	Olmesartan side effects mimic celiac disease.
Jun20	Anti-adhesion molecule therapy for urinary tract infection.
Jun20	Higher urinary sodium output in the PREVEND trial linked to higher BP, uric acid, and albuminuria.
Jun20	Intestinal bacteria secrete neurotransmitters (GABA) that may play a role in inflammation.
Jun13	Healthy human microbiome characterized.
Jun13	Thiazolidinedione use may increase risk of macular edema.
Jun13	Apramycin may be a useful antibiotic that causes little damage to hearing.
Jun07	Abiraterone shows good results in advanced prostate cancer.
Jun07	High caffeine levels protective against Alzheimer disease.
May29	FDA issues warning about use of high total base content hemodialysis solutions.
May29	AUF1 gene plays central role in aging, inflammation, and cancer.
May19	Short-term azithromycin treatment associated with increased cardiovascular death risk.
May19	Study of HDL genetic variants casts doubt on the beneficial impact of higher HDL levels.
May19	New MRI technique can follow changes in brain pH.
May19	Renal denervation shows encouraging results for resistant hypertension.
May04	Mechanism of increased CV risk with NSAIDs explained.
May04	Cardiovascular risks of varenicline not confirmed.
May01	FDA approves everolimus for treatment of kidney angiomyolipomas associated with tuberous sclerosis.
May01	Avastin and Lucentis similarly effective in treating wet age-related macular degeneration.
May01	Interferon treatment can cause depression.
Apr26	FDA issues safety warning about using aliskiren plus an ACEI or ARB in diabetes or CKD.
Apr26	Want more bone cells and less fat cells? Endoglin may be the answer.
Apr17	Proteins can fold in a water-free environment and develop thermal resistance
Apr05	As yet unidentified factor from fat stem cells can markedly increase glucose uptake in muscle.
Mar27	FDA approves peginesatide to treat anemia in adult dialysis patients.
Mar27	LDL antibodies reduce LDL cholesterol by 70% in patients already taking statins.
Mar20	Antiplatelet therapy in CKD patients with heart disease called into question.
Mar13	FDA nd Congress launches initiatives to deal with drug shortages.
Mar08	FDA considering making many drugs over the counter.
Mar08	Silver mouthwash to treat oral Candidiasis.
Mar08	Animal studies suggest that nitric oxide gas inhalation after stroke improves brain perfusion.
Mar08	New class of drugs can reverse fibrosis in injured and diabetes-afflicted kidneys.
Mar02	FDA: Statins and protease inhibitors taken together can increase risk of muscle injury.
Feb28	FDA adds diabetes, memory loss warning to statins.
Feb26	Takeda's GP40 agonist drug lowers blood sugar in type 2 diabetes without hypoglycemia risk.
Feb22	FDA advisory panel votes to approve weight loss drug Qnexa (phentermine/topiramate)
Feb18	Four new drugs will change prostate cancer care.
Feb18	Hypervirulent resistant Klebsiella bacterium is next superbug in waiting.
Feb18	New link identified between insulin resistance ant gut inflammation via fatty acid synthase.
Feb18	Polystyrene nanoparticle block gut iron absorption.
Feb14	Amino acid response pathway, autoimmune disease, tolerance, and a Chinese herb.
Feb14	Paricalcitol fails to improve LVH in CKD patients in randomized PRIMO trial.
Feb09	CDC issues safety alert regarding proton pump inhibitors and risk fo C difficile diarrhea.
Feb09	Bexarotene rapidly clears Alzheimer type plaque from brains of mice.
Feb09	FGF21 (this is NOT FGF23) good for reducing fat mass, but bad for bone density.
Feb09	Coronary artery disease in British males linked to common Y-chromosome haplogroup.
Jan26	Chemists synthesize artificial cell membrane.
Jan12	Routine aspirin may cause harm
Jan10	Dabigatran linked to risk of acute coronary events.
Dec13	CKD may cause breakdown of tight junctions between intestinal epithelial cells.
Dec13	Statins reduce plaque by affecting the CCR7 chemokine receptor on macrophages.
Dec11	One session of gene therapy for hemophilia B leads to prolonged increase in clotting factor.
Dec08	New purine synthesis blocking drug kills malaria parasites.
Dec06	U.S. FDA considering the relative efficacy and safety of Affymax to treat CKD anemia.
Dec06	EPO involved in the spread of cancer.
Nov28	Amgen negotiates 2 large anemia drug contracts with DaVita and Fresenius.
Nov16	ASN; PRIMO study shows no benefits of paricalcitol on LVH in patients.
Nov16	Higher dose statins reduce coronary artery plaque.
Nov16	Niacin may not improve hard outcomes.
Nov09	Potassium channels in the hypothalamus linked to blood glucose control.
Nov01	Am Heart Assoc High BP Research Council Fall 2011 Meeting abstracts
Oct28	Sulodexide fails to show benefit in diabetic kidney disease in large trial.
Oct26	Furanocoumarin-free grapefruit may have less interference with prescription drugs.
Oct26	FDA panel to review anemia drug peginesatide (from Affymax) on Dec. 7, 2011.
Oct26	Apixaban better than warfarin for atrial fibritllation.
Oct26	Taking at least one BP med at bedtime lowers cardiovascular risk.
Oct20	Elderly (over 75 years) die not infrequently due to aggressive prostate cancer spread.
Oct20	Abbott labs to spin off drug division as a separate company.
Oct14	Higher serum 25-D levels of great importance in fighting off tuberculosis infection.
Oct14	Do variants of macrophage inhibitory factor gene account for access infections?
Oct14	Activating fetal hemoglobin production in mice reverses sickle cell disease.
Oct14	Bacteria-derived bile acids linked to efficacy of statins.
Oct14	JASN publishes a series of papers regarding genetic basis of kidney disease risk in Blacks.
Oct14	mRNA-mediated gene regulation shown to be of increasing importance.
Oct11	Thiazides may be especially useful to treat hypertension from calcineurin-inhibitor drugs.
Oct11	Link between FGF23 and LVH strengthened by studies in mice, rats, and patients.
Sep28	Hb target of 11-13 better than 9-11 in predialysis CKD patients accoding to a Japanese randomized trial
Sep27	Eculizumab approved by FDA to treat atypical hemolytic uremic syndrome.
Sep18	Risk of pancreatitis and pancreatic cancer with sitagliptin and exenatide highlighted.
Sep15	Like yourself and other people? It could be due to your oxytocin receptor genotype.
Sep15	DaVita Clinical Research announces biorepository services to facilitate research.
Sep15	MRSA in the United States becoming resistant to combination antibacterial ointments.
Sep15	NEJM: Apixaban better than warfarin to treat atrial fibrillation.
Sep13	Sensipar gets FDA label change focusing on hypocalcemia monitoring and seizure risk.
Sep03	FDA updates kidney failure warning for zoledronic acid (Reclast) osteoporosis drug.
Aug10	Soy tablets of no benefit in preventing bone loss in postmenopausal women.
Aug10	Panfungal vaccine based on injection of killed Baker's yeast?
Aug03	4-D Substudy suggests that low homoarginine levels associate with sudden death.
Jul21	FDA approves ticagrelor (Brilinta) to treat acute coronary syndrome.
Jul21	FDA panel votes against dapagliflozin, casting doubt over the drug class of SGLT2 inhibitors.
Jul21	Knockout model shows that kidney dopamine is an important modulator of blood pressure.
Jul12	Kv7.4 potassium channel in blood vessels linked to control of blood pressure.
Jul05	NSAIDs associated with increased risk of atrial fibrillation.
Jul01	E. coli can survive in streambeds for months.
Jul01	New class of antiangiogenesis drugs discovered from South American tree.
Jun28	Collagen-binding protein allows dental S. mutans bacteria to attach to heart valves.
Jun28	Anticholinergic dugs, including diphenhydramine linked to cognitive impairment and mortality risk in the elderly.
Jun28	NEJM: Bardoxolone methyl improves kidney function in type 2 diabetic patients.
Jun23	NEJM: Telaprevir provides dramatic improvement in hepatitis C patients.
Jun19	E.Coli O104 that causes HUS sequenced and complete genome released.
Jun16	FDA Medwatch: Ongoing safety review in progress re pioglitazone and possible bladder cancer risk.
Jun16	FDA approves Nujolix (belatacept) for organ transplantation.
Jun13	FDA Medwatch: Risk of thyroid calcitonin tumors (in rodents) and pancreatitis with liraglutide.
Jun10	France and Germany suspend approval for pioglitazone due to bladder cancer risk question; other countries not yet.
Jun10	FDA: Finasteride or dutasteride may increase risk of high-grade prostate cancer.
Jun10	Inhibition of insulin degrading enzyme may help control type 2 diabetes.
Jun09	FDA-mandated labeling change for simvastatin regarding risk of higher dosages.
Jun09	SHARP trial (simvastatin plus ezetimibe in CKD) results published in the Lancet.
Jun09	FDA: Myopathy risk of high-dose (80 mg) simvastatin close to 50%; limitations to use recommended.
Jun09	Growing role of antibiotic peptides.
Jun07	Medicare to offer more waivers pertaining to e-prescribing noncompliance penalty.
Jun07	Gene therapy reverses type 1 diabetes in mice.
Jun02	New variety of MRSA originating in animals identified in Europe.
May31	Affymax/Takeda files new drug application (NDA) for peginesatide to treat anemia.
May28	Lactate shuttle in human tumors. Is chronic use of lactate-based PD fluid a risk?
May28	Chronic estrogen exposure may increase blood pressure via superoxide; reversed by resveratrol.
May26	Addition of niacin to simvastatin fails to protect the heart and may increase stroke risk
May24	Turkey tail mushroom found to be very effective in suppressing prostate tumors in mice.
May19	Avandia (rosiglitazone) REMS (Risk Evaluation and Mitigation Strategy) document.
May19	Modifying Treg cells allows transplantation of human skin onto mice.
May19	Deuterium-enriched vitamin A slows rate of age-related macular degeneration in a mouse model.
May19	Study compares three induction immunosuppressants, finds the cheapest one, alemtuzumab, to be noninferior.
May17	FDA advisory panel will convene to reconsider approval of fenofibrate
May16	IDOL, inducible LKL receptor degrading molecule, may be target for cholesterol lowering.
May13	FDA approves boceprevir to treat hepatitis C.
May12	Losartan might protect against disuse muscle atrophy (in mice).
May03	Sodium retention action of thiazolidinediones linked to increased proximal tubular absorption.
May03	Link to EPOGH study in JAMA on urinary sodium and CV death risk.
Apr29	Avastatin equivalent to Lucentis for treating wet macular degeneration, but much cheaper.
Apr29	FDA panel recommends approval of telaprevir for hepatitis C.
Apr28	Viral breakthrough in HBV treatment with nucleoside analogs may be due to noncompliance.
Apr28	Case report of a possible link between kava tea ingestion and rhabdomyolysis in a bicyclist.
Apr28	Vitamin E helps reduce nonalcoholic fatty liver more than metformin in diabetic kids.
Apr26	Boceprevir and telaprevir each show promising results in patients with hepatitis C.
Apr26	25D blood level differences explain 40% of difference in blood pressure between blacks and whites.
Apr22	Pirfenidone gives promising results in treating diabetic nephropathy.
Apr12	Am Acad Neurol issues guidelines regarding treatment of diabetic nerve pain.
Mar30	Antibiotics wrapped in nanofibers show dramatically increased efficacy.
Mar29	Phase 1 safety trials for begin for deuterium-based drug targeting diabetic kidney disease.
Mar29	Nicotine found to increase blood levels of HbA1c in diabetic patients.
Mar25	GAO issues reports on monitoring of oral drugs for ESRD patients
Mar24	Rockwell proceeding with Phase III trial of dialysate-added iron.
Mar24	Ok, you know about FGF23. But FGF19 may be even more important in glucose metabolism.
Mar24	Do you still ask about green or yellow phlegm in your patients who are coughing?
Mar24	Multidrug-resistant Klebsiella pneumonia found in Los Angeles County area acute care hospitals.
Mar21	Canadian observational data suggests that dual ACEI/ARB treatment is risky in the elderly.
Mar17	Cardiac injection of autologous stem cells markedly improves heart failure.
Mar15	11beta-hydroxysteroid dehydrogenase type 1 linked to apple vs. pear-shaped phenotype.
Mar15	Wnt receptor Frizzled-9 involved in bone mineralization.
Mar15	Snapin protein found to control insulin release from pancreatic beta cells.
Mar12	Endothelin-A antagonist atrasentan reduces UACR in diabetics in small phase 2 study.
Mar12	Wnt1 can stimulate new blood vessel formation and also improve blood flow.
Mar05	NEJM paper compares loop diuretic strategies for acute heart failure.
Mar02	Glycogen synthase kinase 3 beta (GSK3B) antibody lowers blood pressure in animals.
Mar02	Self-treatment of drug allergy rash with a tanning be can lead to toxic epidermal necrolysis.
Feb28	Older patients confused about how to time taking of multiple drugs.
Feb28	Gut bacteria can affect hepatic lipid metabolism
Feb24	FDA approves saxagliptin (Onglyza) labeling to include patients with CKD
Feb24	Missing sugar molecule raises diabetes risk in humans
Feb16	Sanofi finally seals the deal to buy Genzyme.
Feb16	Rockwell commences PRIME study of dialysate-added iron.
Feb11	New genetic cause of primary hyperaldosteronism identified, and it's not rare.
Feb07	Pivotal discoveries in age-related macular degeneration.
Feb04	Mutation points to adenosine as playig a role in arterial calcification.
Feb02	NEJM: Fidaxomicin a new, more effective treatment for Clostridium difficile.
Feb01	Sanofi still pursuing offer to acquire Genzyme.
Feb01	FDA adverse event drug reporting system flags several drugs used in CKD.
Feb01	FDA decides to not approve diet drug Orexigen's Contrave at the present time.
Jan27	Who needs insulin? UT Southwestern study shows that without glucagon, insulin may not be that important.
Jan27	Rockwell to launch phase 3 studies of iron-fortified dialysate.
Jan27	Circadian rhythms demonstrable even in red blood cells.
Jan21	Inhaled insulin fails to get FDA approval; 2 additional studies were requested.
Jan15	National Library of Medicine's Daily Med website for quick access to drug package inserts.
Jan14	Coffee, sex (hormones), and diabetes...
Jan12	JAMA: Candesartan linked to better survival in heart failure than losartan.
Jan12	Common painkillers linked to increased risk of vascular complications.
Jan10	Statins may be harmful after hemorrhagic stroke.
Dec28	FDA clears Novartis' triple antihypertensive drug for marketing.
Dec22	Metreleptin a promising new treatment for type 1 diabetes.
Dec03	Fresenius enters into agreement with Galenica pharma to develop new IV iron products.
Nov30	AMAG's Feraheme modifies its labeling, but FDA does not require a black box warning.
Nov30	Prolyl hydroxylase inhibitor FG-2216 results in increased EPO production by ESRD kidneys and liver.
Nov30	Keryx announces positive results for Zernez, an iron-based phosphate binder
Nov30	M3 muscarinic receptor on pancreatic beta cells key to insulin release.
Nov30	Institute of Medicine releases new guidelines for vitamin D intake (600-800 IU)
Nov30	Source of protection against saturated fat (Angptl4) found, and 3% of people don't have it.
Nov23	Propoxyphene withdrawn from the U.S. market due to risk of cardiotoxicity.
Nov21	Bardoxolone INCREASES GFR by a substantial amount in type 2 diabetic CKD patients
Nov18	Statins boost bacterial killing by phagocytes.
Nov17	Radiofrequency zapping of renal nerves in CKD lowers blood pressure substantially.
Nov17	NEJM: New CETP inhibitor anacetrapib shows promise in affecting LDL and HDL levels
Nov16	FDA panel recommends approval of Benlysta to treat lupus flares.
Nov16	Xarelto and other warfarin alternatives about to hit the U.S. market.
Nov14	Large RCT has good news and bad news for nesiritide (Natrecor).
Nov11	Pioglitazone slows down cyst growth in a rat model of PKD.
Nov08	Rush to judgement? Rosiglitazone not linked to heart events in BARI 2D
Nov08	Genistein (from soy) may help prevent spread of prostate cancer cells.
Nov08	Pentazocine stabilizes retina in a mouse model of diabetes.
Nov04	Addition of telaprevir increases hepatitis C cure rates.
Nov02	New liver hormone linked to selenoprotein P associated with insulin resistance.
Oct29	Deuterated fatty acids resistant to oxidative damage.
Oct29	AMAG Q3 report discusses potential black box warning
Oct22	Salt sensitivity linked to vasopressin via induction of brain protein synthesis.
Oct15	NEJM: Regulatory action on rosiglitazone by the FDA.
Oct14	FDA CV and Renal Drugs Advisory Committee meets Oct 18th to consider TREAT study results.
Oct12	Pharmacy benefits group attempts to predict drug non-compliance at an early stage.
Oct09	More on FDA-mandated withdrawal of Meridia (sibutramine) from the U.S. market.
Oct09	Androgen deprivation therapy causes structural bone decay.
Oct09	Abbott removes weight loss drug Meridia (sibutramine) due to stroke and heart disease risk.
Sep25	Octagam IVIG withdrawn from sale due to thromboembolic event risk.
Sep23	FDA to limit patient access to rosiglitazone (Avandia)
Sep23	Abbott Labs buys international rights to CKD prevention drug bardoxolone
Sep23	Three proteins reliably increase in the blood during transplant rejection.
Sep23	European Medicines Agency recommends that Avandia (rosiglitazone) be banned from the European market.
Sep22	Weight-based dosing of taribavirin causes less anemia than ribavirin in hepatitis C treatment.
Sep15	Defective ABCB4 gene impedes cholesterol excretion into the bile.
Sep10	NIH launches beta version of new tool to identify unknown pills.
Sep10	University of Kansas researchers develop compound that reverses diabetic neuropathy in mice.
Sep10	Alzheimer amyloid precursor protein function discovered to be involved with iron storage
Sep09	FDA issues new safety alert re gadolinium-containing contrast agents and NSF.
Sep08	Quercetin (found in onions and black tea) aggravates kidney cancer in rats
Sep03	Cranberry juics blocks ability of Staph aureus bacteria to form biofilm in the urinary bladder.
Sep03	Fish oils inactivate inflammatory effects of macrophages present around fat cells
Sep03	Novel antimalarial drug candidate shows promise.
Sep03	First clinical trials completed on potent new drug against hepatitis C.
Aug31	Could a vaccine against Staph aureus toxin alpha hemolysin (Hla) help in exit-site infection?
Aug31	Large study debunks notion that statins may be associated with cancer.
Aug29	Molecule found that deactivates selective components of the complement system.
Aug26	Genetic variants in protein kinase C affect CKD progression in type 2 diabetics of Chinese descent.
Aug26	Novartis options siRNA drug from Quark Pharma to reduce AKI and delayed allograft function.
Aug26	Back to the future: Renin profiling claimed to be useful in predicting response to RAAS inhibitors or beta-blockers.
Aug26	Naringenin from grapefruits shows promise as a treament for type 2 diabetes
Aug21	KDIGO initiative for improved drug dosing in patients with kidney disease
Aug20	Two FDA approved drugs cause HIV to mutate itself to death in mice.
Aug19	Vitamin D may improve allergic aspergillosis related diseases.
Aug17	FDA approves longer use of (200 days) of valganciclovir for CMV prophylaxis post transplant.
Aug04	CMS implements steps to close donut hole for pharmaceutical funding
Aug02	New drug resistant strain of E. Coli spreading in the U.S. as well as abroad.
Jul30	Calcium supplements increase the risk of heart attack in postmenopausal women.
Jul28	Biotrends data suggests that use of ESAs for stage 4 CKD is falling.
Jul28	Presence of nonhuman sialic acid in biotech drugs can provoke an immune response.
Jul24	Marcrophage fatty acid synthase a new target to prevent atherosclerosis.
Jul21	Glitazones act NOT as PPAR-gamma agonists, but by blocking PPAR phosphorylation by ckd5.
Jul20	Inhaled insulin comes one step closer to FDA approval.
Jul20	FDA approves generic version of transdermal clonidine.
Jul15	FDA review panel shows mixed opinions about whether Avandia should be withdrawn from sale.
Jul09	More on the FDA and Avandia (rosiglitazone) safety issues.
Jul08	Getting forgetful? P7C3 seems to help aging rats.
Jul08	Rosiglitazone safety issues continue to be unresolved. FDA to reveal new data tomorrow.
Jul06	Robert Brenner named CEO of start-up company focusing on use of stem cells to treat kidney disease.
Jul02	Why 25 vitamin D levels may be low in uremia.
Jul02	Honey as a topical antibiotic explained.
Jun24	Selective estrogen compound activates cell-surface receptors only, may confer vascular protection.
Jun22	Wall Street Journal article highlights food - drug interactions.
Jun22	Affymax shares fall after cardiovascular risk concerns raised about hematide.
Jun17	Once-weekly exenatide controls weight and HbA1c in DURATION-4 study.
Jun10	Allopurinol markedly slows progression of CKD in small randomized trial.
Jun10	The secret of why red wine and green tea block some cancers may be revealed.
Jun02	Amgen drug denosumab (Prolia) approved by the FDA to fight osteoporosis.
May26	FDA mandates labels change for proton pump inhibitors warning of fracture risk.
May26	Watson files abbreviated new drug application for sevelamer carbonate.
May18	Teva Pharmaceutical announces tentative FDA approval of generic cinacalcet (Sensipar)
May18	Pregnenolone sulfate may reduce inflammatatory mediator production by blood vessels.
May12	Why multiple drug treatment may be required to treat hepatitis C virus infection.
May11	Proton pump inhibitors increase risk of fractures and of nosocomial C. difficile
Apr28	Eating hot peppers significantly increases (doubles) post-prandial energy expenditure as well as fat oxidation.
Apr28	Anabolic steroid use in healthies impairs left ventricular relaxation by 50% and also ejection fraction.
Apr28	RCT shows that high-dose B vitamins associated with increased risk of progression and CV events in diabetics.
Apr28	Depomedrol and ACTH have different effects on osteonecrosis of the hip, VEGF.
Apr24	FDA approves Zortress(R) - everolimus - for organ transplant use.
Apr11	Nanovaccine stops type 1 diabetes from developing in mice.
Apr07	Heparin tested under the new standard may be 10% less potent than previously.
Mar29	U.S. judge invalidates gene patent
Mar29	Novel antivirus compounds target the viral envelope, and are broadly effective.
Mar28	Toronto conference on Nephroprevention to be held October 1-2, 2010.
Mar23	Novel compound targetting DC-SIGN receptor developed against HIV
Mar22	Effect of UV sunlight rays on multiple sclerosis -- something other than vitamin D at work?
Mar08	Good Vitamin D levels needed for adequate killer T cell function.
Mar04	Pycnogenol (pine bark extract) reduces kidney damage in hypertension.
Mar04	Prostate cancer vaccine (Dendreon) improves survival by 40% in patients with advanced disease.
Mar02	FDA advisory panel recommends approval of belatacept for kidney transplants.
Feb28	Rising threat of infections due to drug-resistant Gram-negative infections
Feb23	AHA/ACC issue Science Advisory re heart risk and thiazolidinedione drugs.
Feb22	Mutations in gene encoding K channel KCNN3 associated with atrial fibrillation.
Feb16	Affymax readies blockbuster alternative to Epogen.
Feb12	NKDEP offers a suggested approach to drug dosing in CKD
Feb12	Tetrahydrobiopterin (BH4) a drug already used in humans, prevents diastolic heart failure in mice.
Feb11	GLP-1 analogue designed to be taken weekly shows promising results in diabetics.
Feb10	3SBio licenses China rights to ferric citrate as a phosphate binder.
Feb01	Serious liver disorder associated with didanosine (drug used to treat HIV) use
Jan27	Think you know how platelets are made? Guess again.
Jan27	Longevity effects of human growth hormone debunked by long-lived deficients.
Jan12	Intranasal and intracranial TGF-alpha restores motor function after stroke in rats.
Jan06	NEJM FDA op ed piece: Time for reevaluation of anemia drugs.
Jan06	FDA plans safety panel on 3 drugs for anemia.
Jan06	Study examines the mathematical benefits of drawing multiple patient lab samples.
Jan06	Genetic survey of clear cell renal cancer samples identifies new gene abnormalities.
Jan05	Vitamin C arrests senescence in mice mutated to mimic Werner syndrome.
Jan05	Glycyrrhizin increases ability of skin to ward off infection.
Dec29	High price of FDA approval - the case of colchicine.
Dec23	Caloric restriction longevity effects linked to telomerase activity.
Dec22	Deoxycytidine kinase enzyme shown to profoundly affect adaptive immune system.
Dec12	Star fruit intoxication in patients with moderate CKD not yet on dialysis
Dec08	FDA panel recommends approval of everolimus for transplant rejection with a risk mitigation plan.
Dec08	Drug reimportation re-emerges in health care debate.
Dec04	Observational study suggests remarkable protection against graft-versus-host disease by statins.
Dec03	Finasteride linked to increase risk of breast cancer in men.
Dec03	What is "pay for delay" and how does it affect availability of generic drugs?
Dec02	Urea concentrations between 10 and 40 mM induce reactive oxygen species in cell culture.
Dec01	TLR2 (toll-like receptors) linked to inflammatory damage in atherosclerotic plaque.
Dec01	Are peptoids that disable autoreactive T cells the next step in treatment of autoimmune disease?
Dec01	Protein Kinase G (PKG) controls brown fat abundance; may be manipulated in treatment of obesity.
Nov27	Stress-related blood pressure linked to phosducin.
Nov26	Rituximab helps preserve beta cell function in patients with early type 1 diabetes.
Nov19	FDA issues warning letters to 22 websites marketing health products with unapproved claims.
Nov18	Niacin plus statin no better than niacin alone in elderly patients with CAD.
Nov18	Genzyme cancels development of Renvela successor.
Nov17	FDA: Omeprazole and clopidogrel drug:drug interaction reducing efficacy of clopidogrel
Nov15	NEJM: Extended-release niacin better than ezetimibe (Vytorin) for atherosclerosis reduction
Nov14	Myostatin inhibitors increase muscle mass and strength in monkeys via gene therapy.
Nov14	Why certain antibiotics like cipro and tetracycline counteract each other
Nov10	Insurers, drugmakers turn to Senate for changes to health care reform bills.
Nov06	1930s gonorrhea drug acriflavine blocks HIF-1 induced new blood vessel proliferation.
Nov05	Benlysta (belimumab) phase III trial for lupus gives positive results.
Nov05	NEJM: Hematide corrects anemia due to ESA-induced pure red cell aplasia.
Nov04	FDA unveils "Safe Use Initiative" to reduce medication-related side-effects.
Nov04	TLR4 on macrophages may mediate the immune system response to excess fat.
Nov04	ROMK downstream pathway clarified; may lead to new drugs to combat hyperkalemia in CKD
Nov03	FDA warns about adverse renal effects of Byetta (exenatide)
Nov03	One particular MRSA strain associated with high mortality rates.
Nov03	Proton-pump inhibitors associated with multiple side effects.
Oct30	TREAT trial of darbepoetin in diabetics with preESRD shows no benefit and increased stroke risk.
Oct29	Rockwell announces completion of Phase IIB study of dialysate-supplemented iron therapy.
Oct28	50K or ergocalciferol every 2 weeks as maintentance treatment for vitamin D deficiency.
Oct28	Shire's Fosrenol approved in Europe for preESRD patients
Oct28	Fish oil (DHA) metabolite resolvin 2 found to have marked anti-inflammatory activity
Oct28	Gut bacteria linked to diet, immune system functioning via short chain fatty acid receptor
Oct26	Histone released from damaged cells during trauma or sepsis damages blood vessels.
Oct23	FDA authorizes use of IV peramivir for hospitalized patients with H1N1 infection.
Oct23	FDA Medwatch reports another case of PML after rituximab in a rheumatoid arthritis patient.
Oct19	Black box warning for Dexferrum (iron dextran) modified after anaphylactic reactions.
Oct19	FDA delays approval of Amgen's denosumab to treat osteoporosis.
Oct19	Uloric shown particularly effective in lowering hyperuricemia in patients with mild-moderate CKD.
Oct15	The gadolinium NSF story from the product liability perspective, focus on G.E.
Oct01	FDA announces new manufacturing standards for heparin that may change its potency.
Sep25	Januvia (sitagliptin) linked to increased pancreatitis risk
Sep24	200g/day fructose supplement increases systolic BP by 6 mm Hg, prevented by allopurinol.
Sep24	AJKD issues containing KDOQI guidelines now freely available as .pdf files
Sep18	Metformin or insulin do not lower levels of inflammatory markers in diabetics.
Sep13	Multidrug resistant Staph aureus recovered from 7 public beaches around Puget Sound.
Sep11	Fresenius launches telemonitoring system for dialysis patients.
Aug30	NEJM: Ticagrelor better than clopidogrel as an anti-platelet agent post acute coronary syndrome.
Aug30	NEJM: Free full text paper on dabigatran vs. warfarin for stroke prevention in atrial fib.
Aug30	Pradaxa (dabigatran) outperforms warfarin by a mile for stroke prevention with a. fib.
Aug28	About 1/3 of people don't activate clopidogrel very well due to gene variants.
Aug28	High LDL cholesterol may thin bone by stimulating RANKL.
Aug28	New gene controlling formation of adipocytes identified.
Aug24	Mice eating a low-carb diet show increased atherosclerosis and decreases in vascular progenitor cells.
Aug24	FDA announces ongoing monitoring of liver injury associated with Orlistat.
Aug21	Oxidative stress in CKD patients linked to malfunctioning mitochondria.
Aug21	Excess cholesterol can affect heart rhythm via potassium channels
Aug21	When vitamin D levels low, macrophages get overloaded with cholesterol.
Aug19	Vitamin D regulation of immune function via cathelicidin conserved in all primates.
Aug19	Heart failure risk with rosiglitazone double that with pioglitazone.
Aug19	Pot for prostate cancer.
Aug19	Klotho gene reduces blood pressure and extends lifespan.
Aug18	Pharmacologic development of sirtuin activators - reviewed in NY Times
Aug13	Toray develops insulin nasal spray.
Aug11	GIFT15 treatment modified B lymphocytes and reverses multiple sclerosis in the lab; may have potential in lupus as well.
Aug11	Gene therapy restores alpha-1-antitrypsin activity in lungs of patients with hereditary deficiency.
Aug11	Anti-RAS drug restores insulin production in animal model of diabetes.
Aug11	Release of fat-stored substances during dieting or other weight loss: Example of cannabis.
Aug06	Itch-specific neurons identified in mice.
Aug06	Hypertension associated with VEGF-inhibitors linked to nitric oxide.
Jul31	FDA approves saxagliptin for use in type 2 diabetes.
Jul31	FDA warns of colchicine side effects when co-prescribed with clarithromycin and other drugs.
Jul31	Resveratrol found to have potent anti-infammatory effects.
Jul31	Lecithin found to have beneficial effects on fat metabolism via PPAR-alpha
Jul31	Avasting (bevacizumab) may be potent treatment for diabetic macular edema.
Jul30	Cell biology mechanisms of genistein (present in soybeans) inhibition of prostate cancer clarified.
Jul28	NIH halts trial of sildenafit in patients with sickle-cell disease and pulmonary hypertension.
Jul28	How do drugs like cromolyn that affect mast cells affect adipocytes and metabolic syndrome?
Jul28	Defer0xamine to treat diabetic foot ulcers? In mice, yes.
Jul23	Clinical trial of injecting pig insulin-producing cells into humans begins.
Jul19	HGS/Glaxo drug Benlysta shows some effectiveness against lupus in phase 3 clinical trial.
Jul14	Senate backs 12 year non-compete shelter for biotech drugs
Jul13	DaVita Clinical Research appoints Dr. Mahesh Krishnan as Vice President
Jul08	Costimulation blocker plus alefacept allow monkeys to tolerate transplanted kidneys.
Jul08	Is PEDF "the" link between obesity and type 2 diabetes?
Jul08	Anti-ageing effects of rapamycin in mice in the news.
Jul05	Aldosterone regulates ENac levels via Per1 - a protein mediating circadian rhythms.
Jul02	Fresenius opens specialty pharmacy for renal patients in Nashville.
Jul02	NEJM: Phospholipase A2 receptor is a target antigen in 70% of patients with idiopathic membranous nephropathy.
Jul02	Rebound hyperacidity, reflux symptoms in normals after stopping proton pump inhibitors
Jul02	Enalapril or losartan markedly slow progression of eye damage in type 1 diabetics.
Jul01	FDA advisory panel recommends banning Vicodin and Percocet and limiting maximum acetaminophen doses
Jun30	Common gene polymorphism affecting calcium excretion (claudin 14) linked to both kidney stones and osteoporosis.
Jun26	Mechanism of BPA (bisphenol A) related infertility defined in mice.
Jun20	New prostate cancer drug ipilimumab shows dramatic results in 2 patients.
Jun13	FDA issues alert on increased death risk in liver transplant patients taking Rapamune.
Jun13	Sevelamer carbonate (Renvela) approved for sale in the European Union
Jun10	Ferric citrate found to bind phosphate in phase II study with no marked adverse effects.
Jun05	Aldosterone levels found to be increased in chubby teenage boys.
Jun05	Telaprevir substantially increases hepatitis C cure rates (NEJM)
Jun04	Halofuginone, Th17 cells, and autoimmunity.
Jun03	FDA reports on serious liver failure risk in patients taking propylthiouracil.
May29	FDA: Serious fungal infections associated with TNF-alpha blockers.
May29	Risks of aspirin outweight benefits for primary prevention of stroke, MI in those with normal kidney function.
May26	FDA approves Samsca (tolvaptan) to treat hyponatremia.
May25	Search all abstracts from the World Congress of Nephrology 2009
May22	New anti-inflammatory drug candidate works by releasing hydrogen sulfide gas.
May22	Drinking from polycarbonate bottles for a week increases urinary bisphenol levels.
May19	NF-kappaB inhibitor might be ideal drug to combat osteoporosis and periodontitis.
May18	Edible vaccine against p24 protein of HIV elicits an antibody response in mice.
May15	Interventional study in mice links cytomegalovirus infection to high blood pressure.
May15	Metformin shown to act directly via CBP glucose-regulating protein in the liver.
May14	Monotherapy with DARA, an endothelin and angiotensin I receptor antagonist, lowers BP a lot.
May11	UMOD gene, associated with Tamm-Horsfall protein production, linked to kidney disease.
May11	Cyclophilin may play a key role in arterial damage associated with atherosclerosis.
May08	FDA approves generic version of mycophenolate mofetil
May07	Calcimimetics inhibits late-stage cyst growth in an animal model of ADPKD.
May05	Fresenius launches national retail pharmacy for dialysis patients.
May01	Survey company releases report on usage trends for vitamin D, phosphate binders, and calcimimetics.
Apr30	Januvia (sitagliptin) pancreatitis risk suggests potential drug class effect on the pancreas for GLP-1 enhancers.
Apr27	Potential importance of vitamin D receptor, commensal bacteria, and olmesartan in autoimmune disease.
Apr27	Biotech companies, including Baxter, scramble to respond to flu epidemic with vaccines.
Apr26	Prostaglandin 2-alpha may be new target for control of blood pressure and atherosclerosis.
Apr23	Bacteriophage used to successfully treat chronic Pseudomas ear infection
Apr22	Alzheimer beta-amyloid can be degraded, and some drugs can increase breakdown rate 7-fold.
Apr18	Ultrashort-acting prednisolone derivatives (antedrugs) stop inflammation and then are metabolized to avoid side effects.
Apr17	New discoveries on how collagen activates platelets may lead to new treatments to prevent clotting.
Apr16	Endothelin A receptor antagonist darusentan shows promising results in resistant hypertension.
Apr16	Provenge prostate cancer vaccine significantly prolongs survival.
Apr12	CXCL5, secreted by white adipose tissue, may be the link between obesity and inflammation and insulin resistance.
Apr11	One thousand 2007-2009 audiofiles and slide/audio talks added to HDCN's 20 topic-related channels.
A06	Impax, a generic drug manufacturer, challenged by Genzyme with Renvela patent.
M30	Variants of nisin, an FDA-approved antibiotic used in food preservation, show effectiveness against MRSA.
M30	FDA approves mTOR inhibitor everolimus for treatment of advanced kidney cancer.
M29	Link to slide/audio and audio symposia on HDCN
M25	Thymoquinone protects pancreatic beta cells from oxidative effects of protease inhibitors; a renoprotective role as well, maybe?
M22	Protein in yellow peas lowers BP by 20% in animal model of PKD.
M20	FDA panel gives nod to alternative to warfarin
M18	Another statin (Crestor, rosuvastatin) fails to show a benefit (rumor has it) in dialysis patients.
M17	Endothelial lipase linked to levels of good cholesterol
M10	Bacteriophage-derived enzyme Cpl-1 better than amoxicillin in treating pneumococcal pneumonia.
M09	Cranberry juice proanthocyanidins, and not low pH, impair E. Coli attachment to urinary bladder endothelium
M04	FDA December, 2008 drug labeling changes (including Sensipar, CellCept, Actos)
M04	Pharma consultancy of medical school faculty members in the news.
M03	AMAG hopeful that the FDA will approve its injectable iron supplement.
F27	FDA warns of tardive dyskinesia risk with Reglan (metoclopramide)
F26	Clavulanate plus meropenem found to be surprisingy effective in vitro against multidrug-resistant TB
F18	NEJM: Genetic testing helps predict warfarin dose.
F18	Study suggests that warfarin dose needs to be lower in patients with CKD.
F16	FDA approves Uloric (febuxostat) for treatment of gout.
F12	FDA and consortium release first data on genetic associations with serious drug adverse events.
F06	FDA approves antithrombin derived from the milk of genetically-modified goats.
F05	Sensory nerves in fat cells help regulate lipolysis, according to animal study.
F02	Leprosy drug clofazimine holds promise as an immunomodulatory agent.
J31	FDA advisory panel recommends that Darvon (propoxyphene) be pulled from the marked due to suicide risk, low efficacy.
J30	Epoxide hydrolase inhibitor reduces heart failure in animal model
J28	Genzyme shares climb after Amgen abandons development of phosphate drug.
J17	Kidney injury biomarker panel now commercially available for animal testing of new drugs
J16	Mutations in gene regulating melatonin-mediated insulin secretion increases type 2 diabetes risk
J15	New family of antibiotics isolated from hydras and leeches.
J15	HipA, a protein kinase, involved in bacterial dormancy, allowing survival during antibiotic therapy.
J10	FDA expert panel recommends approval of drug (antithrombin alfa) extracted from the milk of genetically-engineered goats.
J09	New anti-anginal drug acts by working on sodium channels.
J09	Human insulin produced by genetically modified safflower plants ready for testing.
J08	Quest Diagnostics acknowledges errors (mostly overestimation) in vitamin D tests.
D18	FDA raises the bar for new diabetes drugs
N19	Did you know that your prescribing history is for sale? Fed appeals court supports NH law banning the practice.
N19	FDA advisory panel greenlights anti-MRSA antibiotic telavancin, but not approved by the FDA yet.
N18	New microRNA compound protects mice against heart failure.
N18	Five days of cipro cause pervasive and persistent changes in gut microflora abundance.
N14	Renal Week: Relative vitamin K2 deficiency linked to vascular calcification in ESRD
N09	Rosuvastatin given to patients with normal cholesterol levels but high CRPs markedly lowers CV risk.
N06	Ghrelin-like drug increases muscle mass by 20% in the elderly.
N04	Strange, complex pharmacokinetics of methotrexate in RBCs have implications for clinical treatment.
O29	Animal studies suggest potential benefits of drug holiday for patients taking sulfonylureas.
O28	Topical treament for HSV cold sores achieves same results as oral systemic therapy.
O28	Plavix (clopidogrel) may be inactivated by some calcium channel blockers.
O27	Risks of irregular heartbeat and atrial fibrillation increased with fosamax and other bisphosphonates.
O27	Pentoxifylline lowers proteinuria alone or in addition to an ACE inhibitor.
O23	Hydrogen sulfide may be a key regulator of blood pressure.
O23	European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
O17	FDA creates drug safety information webpages for patients and health professionals.
O14	Resveratrol found in dark chocolate and cocoa.
O14	Alpha-1-antitrypsin therapy expands beta-cell populations in the pancreas of mice with a model of type 1 diabetes.
O13	A series of abstracts presented at CRF meeting suggesting that triple anti-platelet therapy (adding cilostatzol) improved outcomes.
O07	Study illustrates importance of inflammatory macrophages in obesity; insulin resistance reversed by killing these cells.
O07	One mechanism whereby ingestion of fatty foods (but not carbs or protein) can suppress hunger identified : OEA.
O06	One-dollar-a-month polypill containing ASA, thiazide, ACEI, and statin to undergo clinical testing.
O03	On Nov 3, U.S. Supreme Court to hear key product liability court regarding use of FDA-recommended drug labels.
S26	Aptly named horny goat weed found to be a source of specific phosphodiesterase inhibitors.
S25	Diabetic gastroparesis in mice reversed by restoring defective hemo oxygenase production.
S22	Darapladib slows atherosclerosis in a pig model.
S18	Are statins ineffective for protection against cardiovascular risks in women?
S16	How should one properly dispose of unused drugs? No one seems to know.
S16	Chamomile tea cuts diabetes complications (in rats)
S16	Conbining thiazides with potassium-sparing diuretics markedly lowers cardiovascular mortality.
S15	Carvedilol and alprenolol, but not other beta-blockers, stimulate cellular protective pathway in the heart.
S14	Hospitals and nursing homes contribute to water contamination with pharmaceuticals through their disposal methods.
S11	Rituximab prescribing info revised to reflect risk of progressive multifocal leukoencephalopathy.
S10	Molecular mechanism of steroid-induced fatty liver determined.
S10	Pentazocine shows encouraging results in a mouse model of diabetic retinopathy.
S09	Serotonin transport receptor levels in the brain change with the seasons; may reflect seasonal affective disorder.
S08	Once-a-week sustained release exenatide lowers HbA1c better than twice daily shots.
S08	Genetic variants associated with markedly different vitamin B12 handling.
S05	Bisphenol (present in polycarbonate plastics) linked to metabolic syndrome.
S02	In vitro studies suggest role for antihistamine clemizole in treating hepatitis C
S02	AJKD: Temporary iron depletion and relative thrombocytosis may underline increased mortality with high doses of EPO.
A29	Singh and Furberg editorialize against use of thiazolidinediones due to CV risk and lack of CV benefit.
A26	Allopurinol lowers blood pressure in hypertensive adolescents
A26	Leptin injections keep rats with type 1 diabetes alive without insulin.
A26	Twenty percent of Ayurvedic medicines found to be contaminated with lead, arsenic, or mercury.
A22	Some evidence that Vytorin is, or maybe is not, associated with an increased cancer risk; FDA gets involved.
A22	New antimicrobial approach tames, rather than kills, pathogenic bacteria, lowering risk of emerging resistant strains.
A21	AMAG receives fast track designation from FDA for ferumoxytol as an MRI contrast agent.
A20	Individual genome analysis shows that drug sensitivity may be poorly predicted by skin color (presumed race)
A19	Effect of grapefruit juice on drug absorption and metabolism: new complexities
A18	Researchers create milligram quantities of completely synthetic heparin
A14	SpyCEP identified as key element to infectivity of group A strep associated with necrotizing fasciitis.
A07	Bile acids play a role in glucose metabolism and insulin signaling.
A01	FDA forces new labeling changes for ESAs under new law.
J31	Two new drugs have profound effects on exercise conditioning in mice.
J23	NEJM: Genetic mutation associated with most patients who develop myopathy on high-dose statins.
J22	House Appropriations Subcommittee increases proposed FDA budget by more than 20% to over 2 billion dollars per year.
J21	Anti-bacterial actions of cranberry juice explained by its action on fimbriae.
J16	Doctors hopeful that improved blood thinners are on the horizon: Three new candidates.
J13	Histone deacetylase (HDAC) inhibitor SAHA found to have anti-immune effects in graft vs. host disease.
J11	FDA lists May 2008 labeling changes: Aranesp (tumor progression) and CellCept (lymphoma and PML risk)
J10	Aspirin may benefit patients with osteoporosis: a possible mechanism identified.
J10	Histone deactylase (HDAC) inhibitors protect ischemic tissue from injury.
J09	Fresenius signs sublicensing agreement with Luitpold to use Venofer in United States patients.
J08	Stanford researchers find molecule that kills kidney cancer cells, STF-62247.
J08	FDA adds boxed warning on risk of tendon rupture associated with fluoroquinolone antibiotics.
J07	Fresenius Medical buys heparin-maker APP pharmaceuticals.
J03	Statins spur glial progenitor cells to develop into oligodendrocytes.
J03	Pfizer will no longer work directly with for-profit CME companies.
J03	FDA panel recommends that all new diabetes drugs be screened for cardiovascular risk.
J02	New orally active, broad-spectrum angiogenesis inhibitor may be useful against many cancers.
J28	Bill to approve pathway for FDA approvals of biosimilars advocated as saving billions of dollars.
J26	Two siRNA in the Phase I/II pipeline for kidney disease, one for delayed graft function, the other for AKI
J24	Take your meds and have a chance at winning the lottery.
J23	Rapamycin may impact retardation in tuberous sclerosis and might be useful in treating autism.
J19	FDA cautions about increased mortality in elderly patients with dementia who had been treated with antipsychotic drugs
J18	Computer generated warfarin dosing as effective as dosing by expert prescribers.
J13	FDA and EMEA to consider biomarkers of renal injury in animal studies evaluating renal safety of new drugs.
J12	XBP1, stimulated by a high-carb diet, may be a new target for treatment of dyslipidemias.
J12	FDA approves generic form of ramipril made by Lupin pharmaceuticals.
J11	CMS gives researchers access to parts of the Medicare prescription drug benefit database.
J05	FDA: More on the ongoing review of TNF-blockers and cancer risk.
J05	Study in mice suggests resveratrol has marked cardioprotective effects.
M23	FDA to use Medicare claims data to monitor drug side effects once drugs have been marketed.
M19	Protein the mimics phagocyte defensins effective against resistant bacteria on in vitro testing.
M18	New superdrug may be useful against MRSA superbugs.
M17	FDA convenes to examine impact of direct-to-consumer pharmaceutical, and now, medical device, advertising.
M13	Texting kids to take their medicine may increase compliance.
M09	Darapladib lowers the activity of inflammatory enzyme associated with vascular plaque.
M05	ASN Renal Week abstract archives 2003-2006 now available on-line in .pdf format.
M02	New ACE 2 activator compounds lower blood pressure in rats and also reduce cardiac and renal fibrosis.
A28	FDA approves Relistor (methylnaltrexone) for opioid-induced constipation.
A25	First ever activator of ENAC sodium channel developed.
A24	GAO says that FDA lacks resources to inspect non-US drug suppliers; only 8% are being inspected now.
A23	Genzyme to build new research and development center in Beijing.
A23	Some compounds in Chinese bitter melon identified with activity against diabetes.
A22	CMS releases standards for e-prescribing of drugs.
A21	Massachusetts Senate unanimously passes a law banning all pharma gifts to doctors.
A19	Democrats propose labeling requirements for food and drugs which would list country of origin.
A10	FDA notice regarding investigation of mycophenolate mofetil regarding progressive multifocal leukoencephalopathy.
A07	New antimicrobial proteins identified in alligator blood
A04	AMAG Pharma presents data on new iron supplement at NKF Spring Clinical Meeting.
A03	New Merck heart failure drug rolofylline gives encouraging results in Phase III trial.
M27	Keryx ends development of sulodexide after negative trial results.
M19	Roche agrees to pay Amgen 22.5 percent royaty on Mircera sales in the U.S.
M13	FDA Oncologic Drug Advisory Panel recommends continued indication of ESAs for cancer patients excluding breast and head and neck.
M12	Keryx diabetes drug sulodexide fails to achieve primary endpoint in phase III clinical trial.
M11	Eli Lilly follows Pfizer and NovoNordisk in discontinuing inhalable insulin.
M10	FDA plans to ease restrictions on dissemination of reprints by pharma involving off-label usage of drugs.
M07	Bill to encourage e-prescribing for Medicare-reimbursed encounters likely to pass this year.
M06	More on the heparin contaminant in Baxter's product line - still unidentified.
M05	Massachusetts may ban drug industry freebies for docs.
M05	Supreme court votes 4 vs. 4 regarding pharma immunity from product liability for FDA-approved prescription drugs.
M05	FDA finds possible contaminant in Baxter heparin.
M05	Sensor necklace and magnetic trace additive to pills might be used to track medication compliance in clinical trials.
F27	Supreme Court hears arguments as to whether pharma companies should be protected from torts when a drug has been approved by the FDA.
F26	FDA: Medication guide must be given to patients with each rosiglitazone (Avandia) prescription.
F20	AMAG submits NDA to FDA for ferumoxytol.
F16	FDA issues draft guidelines for comment to Pharma about distributing reprints describing off-label usage of drugs.
F16	Baxter heparin case calls attention to Chinese chemical companies supplying drug raw materials with minimal regulation.
F16	Promising early data from another prostate cancer vaccine trial.
F15	Some cholesterol synthesis inhibitors also block Staph. aureus pigment synthesis, rendering the germ less pathogenic.
F07	FDA warns on adverse effects due to intravenous colchicine.
F01	Anti-leishmaniasis drug miltefosine kills HIV-infected macrophages, eliminating one protected site of HIV persistence.
J28	Vytorin lowers cholesterol, but does not impact on endpoints; House asks FDA to reconsidering hard vs. soft endpoints in proving drug value.
J25	Cox-2 inhibitors can cause arrhythmias by affecting potassium channels in the heart.
J16	FDA warns of name confusion between two edetate compounds used for chelation.
J11	Gas6 protein may augment the action of erythropoietin
J09	Cannabinoid receptor blocking drug effective in causing weight loss.
J02	Labeling on adrenaline vials in terms of concentration are confusing, lead to errors.
J02	European study could find no link between non-phenacetin pain killers and ESRD
D27	FDA approves synthetic starch-based volume expander fluid.
D27	New orally active cyanide antidotes discovered.
D21	Animal study suggests that EPO may protect hearts against toxicity of anticancer drugs
D20	FDA issues draft guidelines to industry for reporting adverse events linked to OTC drugs and dietary supplements.
D19	Northwestern University gets 700 M royalties for diabetes pain drug patent.
D19	AMAG pharma submits new drug application to FDA for ferumoxytol.
D17	US House Rep Waxman leaks FDA planned guidance to OK drug company promotion of off-label uses of drugs.
D17	Drug that stimulates thyroid hormone beta receptors effective in lowering LDL cholesterol
D15	U.S. FDA considers allowing a new group of -behind the counter- drugs to be dispensed with pharmacist approval only.
D14	FDA warns of serious adverse reactions with iron chelator Exjade.
D08	FDA launches new drug safety newsletter. Here is the first issue (rituximab)
D05	Dennis Quaid sues Baxter over label similarities between low- and high-dose heparin vials.
D04	FDA approves study of iron-containing dialysate additive for hemodialysis patients.
D03	Pharma companies to develop IgA proteases as a potential treatment for IgA nephropathy.
D03	Topical cleaners containing benzethonium chloride bactericidal against MRSA.
N27	FDA: Use of mycophenolate mofetil during pregnancy associated with increased risk of pregnancy loss and congenital malformations.
N26	Nitrosyl cobamide shows promise as an NO-donor type of drug for hypertension or heart disease.
N25	Executives from Genzyme and Johnson and Johnson to sit on FDA foundation board.
N16	CMS pushing e-prescribing for Medicare beneficiaries.
N16	Pramlintide-leptin combination drug induces 13% weight loss in obese patients.
N15	FDA approves Roche ESA anemia drug Mircera
N14	Cattle vaccine shown to be effective in lowering rate of toxigenic E. Coli carriage.
N14	FDA adds black box warning of heart attacks for Avandia (rosiglitazone)
N09	Placenta cloaks its proteins with phosphocholine (as do parasitic worms) to evade immune detection.
N08	FDA modified boxed warnings, indications, for ESA drugs.
N08	Skeletal muscle damage due to statins may operate through atrogin-1 and thus may be preventable.
N06	Shire announces results of Fosrenol trial in stage 3-4 CKD patients.
N05	New vascular function of hemoglobin, as a promoter of nitric oxide synthesis, identified.
N01	Legislation introduced in the House to fight spread of drug-resistant bacteria.
O29	Bacterial use peptides to communicate with each other: extracellular death factor identified.
O25	Bayer issues additional guidance to physicians about Trasylol (aprotinin).
O25	Genzyme launches cholesterol-binding drug (Cholestagel) in Europe for patients with primary hypercholesterolemia.
O25	SQ109, promising anti-tuberculosis drug, given special status by European and U.S. regulators.
O25	Genzyme profits increase tenfold on sales of drugs to treat rare diseases.
O23	Acute pancreatitis associated with exenatide (Byetta) - FDA requires labeling change
O19	Sudden hearing loss associated with erectile dysfunction drugs.
O17	Vaprisol (conivaptan) study shows increase in serum sodium in euvolemic hyponatremia.
O17	FDA advisory committee votes in favor of phosphate binder use for stage 4 CKD.
O16	FDA approves Doribax(tm) - doripenem - for complicated urinary tract infections, including pyelonephritis
O16	Velcade (bortezomib) for multiple myeloma now approved for use in patients with impaired renal function.
O12	FDA advisory meeting next Tuesday to study use of phosphate binders in pre-ESRD - Genzyme, Shire, Fresenius will all be present.
O12	Statins help preserve lung function during aging.
O08	New antibiotic ceftobiprole very effective in curing diabetic foot infections.
O03	Rockwell begins dosing patients with iron (soluble ferric pyrophosphate) - containing dialysate.
S25	New, synthetic version of heparin is patented.
S25	FDA to screen all direct-to-consumer (DTC) television ads if pending law is passed.
S20	Rockwell begins enrollment into Phase IIIb trial of dialysate sodium ferric pyrophosphate for iron therapy.
S11	Nabi to sell its Biologics division, and plans to move its headquarters.
S06	FDA approves first generic versions of carvedilol (Coreg).
A30	New mechanism of action of thiazolidinediones discovered.
A21	Unlike grapefruit juice, pomegranate juice does not appear to affect cytochrome P450-3A activity
A19	Bacteriophage treatments coming back into favor to combat superbugs such as MRSA.
A17	Patients who develop kidney failure after use of phosphate-based laxatives initiate lawsuits.
A17	FDA warning letter issued emphasizing pharmacogenomic variability in warfarin metabolism among patients.
A08	Annals: New study questions the increased heart attack risk with Avandia; original NEJM meta-analysis claimed to have been flawed.
A07	Publix supermarkets to offer up to 14-days of free antibiotics.
J30	FDA Advisory Panel to explore safety and risks of Avandia.
J24	Ferumoxytol Phase III clinical trial results achieve desired endpoints.
J21	New Cochrane analysis focuses on increased side effects in patients taking rosiglitazone (Avandia)
J19	Weight loss pill rimonabant associated with increased suicide risk.
J16	Older, cheaper pills just fine to treat diabetes.
J16	Affymax announces phase 3 development program for Hematide.
J12	Hydroxychloroquine (Plaquenil) may be protective against developing type 2 diabetes.
J09	FDA warning: precipitation when infusing ceftriaxone with calcium-containing solutions.
J27	Amgen makes labeling changes for Sensipar - no longer labeled for use in pre-ESRD patients.
J22	FDA approves pregabalin (Lyrica) for treatment of fibromyalgia.
J22	FDA clears "computerized medication box" (EMMA) for U.S. market.
J19	Randomization complete for phase III trial of sulodexide for diabetic nephropathy.
M23	Diethylene glycol - contaminated toothpaste linked to source in China
M23	Iron-chelating agent defasirox (Exjade) associated with acute renal failure.
M03	NEJM: Drug risks and free speech - can Congress ban direct-to-consumer ads?
A30	Compound from bullfrogs has marked anti-MRSA activity.
A07	Arthritis patients with CVD who take ibuprofen plus aspirin may greatly increase their cardiac risk.
M26	Tolvatptan improves signs and symptoms in patients with CHF.
M26	Nesiritide safety trial shows neutral effect on mortality in CHF patients
M22	FDA moves to limit participation of MDs with ties to pharma companies on its advisory boards.
M12	Azole antifungal drugs found to be active against tuberculosis.
M08	Indian pharma firm Biocon unveils suite of immunosuppressive drugs aimed at the transplant market.
M06	FDA approves aliskiren for treatment of hypertension.
M05	Taking amphotericin B in oil by mouth may result in good efficacy, less renal toxicity.
M02	NEJM: Vancomycin-induced thrombocytopenia: the article link
F28	NEJM: Immune-mediated thrombocytopenia linked to vancomycin use.
F23	MMWR: Nephrogenic fibrosing dermopathy.
F05	FDA approves new dosing recommendations for Rapamune (sirolimus) in high immunologic risk transplant patients.
F01	Biotrends report of Dec 2006 survey on use of ESAs and phosphate binders.
J16	DNA test to be used to determine warfarin dose.
J15	House passes Medicare drug bill.
J09	Two Wisconsin companies get together to develop ingested products for hyperphosphatemia control.
J09	Potential bias in studies funded by the food industry or by pharma in the news.
J04	Genzyme files new drug application with the FDA for sevelamer carbonate.
J03	Renal Advantage completes acquisition of Renalab.
D31	Gene knockout technology creates healthy, prion-protein-free cows
D29	FDA evaluating safety of products from cloned animals; seeks outside comments.
D28	Advanced Magnetics stock surges on hopes for ferumoxytol.
D22	FDA announces that it is still evaluating a possible link between MRA with gadolinium and nephrogenic fibrosing dermopathy.
D22	Multidrug resistant E. coli linked to antibiotic use on farms in the U.K.
D21	Genzyme files for FDA approval of sevelamer carbonbate - Renvela.
D20	FDA to require labeling changes for acetaminophen and for NSAIDs to highlight potential risks.
D16	FDA updates labeling for Trasylol (aprotinin) regarding risk of renal dysfunction, anaphylaxis, and re-exposure.
D12	Phase 3 trial shows Avastin (bevacizumab) improves progression-free survival in renal cancer patients.
D12	FDA campaigns against use of quinine for conditions other than malaria; cautions against use of quinine for leg cramps.
D11	FDA proposes rules overhaul to expand access to experimental drugs.
N30	Dynavax stock rises on news of positive results for Hepatis B vaccine in difficult to immunize patients.
N28	Genzyme researchers show promising results with drug against polycystic kidney disease.
N26	HDCN: Search index updated for audiofiles, slide/audio talks, articles, and abstracts
N18	CMS plans to open up physician-prescribing drug database to researchers
N14	Nabi reaches deal with hedge fund on directors, chairman.
N10	FDA approves pramipexole (Mirapex) for treatment of restless legs syndrome in nonuremics
N10	FDA considers expanding patient access to experimental medications
O30	Pharma supported patient education sites under the microscope.
O26	Phase 3 trial design for belimumab to treat SLE approved by FDA
O23	FDA approves once-a-day Coreg (carvedilol) CR for 3 cardiovascular indications
O18	Cockcroft Gault equation (modified) better than MDRD for adjusting vancomycin dose in the elderly.
O18	Rockwell submits dose ranging study for dialysis solution iron supplement to FDA
O17	FDA approves new treatment for diabetets - Januvia (sitagliptin)
O10	Biodegradable gel stops bleeding promptly
S28	Amgen colon cancer drug gets FDA approval
S28	Meditor working on development of intradialytic hypotension drug.
S27	U.S. House and Senate pass bill allowing purchase of drugs from Canada
S27	La Jolla Pharm announces addition of new sites, reactivation of Riquent (abetimus) study to treat lupus.
S26	Generex develops metformin-containing chewing gum, oral insulin spray, as novel drug-release products.
S19	FDA approves posoconazole to treat Aspergillus and Candida fungal infections.
S18	Food and drugs pass through the stomach very quickly or quite slowly.
S13	More bad news in JAMA paper about CV and kidney risks of COX-2 inhibitors and NSAIDS
S12	New class of pain relievers may help, not hurt, the heart
S11	Advanced Magnetic (ferumoxytol) hires Brenner, Salem, in top positions
S11	Bacterial conversation stoppers may block formation of biofilm
S11	Chitosan (from crabs and shrimp) found to block formation of biofilm.
S11	Want to fight fat? Eat brown seaweed!
S06	Advanced Magnetics completes enrollment for phase 3 trial of ferumoxytol IV iron.
S06	Virtually untreatable type of tuberculosis being identified worldwide
A24	FDA proposes system to systematically register and uniquely identify all drugs sold in the U.S.
A19	Spray on bacteriophages approved to control Listeria on meat; toxigenic E. Coli next on the list.
J31	Survey of FDA scientists documents political interference in drug approval process
J24	Rockwell gearing up to study efficacy of dialysis solution-based iron therapy.
J21	Fresenius to debut calcium-acetate / magnesium-carbonate phosphorus binder in Germany.
J20	New antibiotic tygecycline available in the UK to treat MRSA.
J10	Some drug metabolism / detoxification has a pronounced circadian rhythm.
J02	Cytochroma acquires Proventiv Therapeutics to commercialize new Vitamin D products for CKD market
J28	How to restrict access to your medication prescribing data
J28	Did you know that drug companies have full access to your medication prescribing data?
J20	ISMP and FDA issue medical abbreviation blacklist - QOD, IU, ug, qHS, all likely to cause errors (pdf)
J07	Congenital malformations with first-trimester ACE-inhibitor therapy.
J05	Isis Pharma gets orphan drug status for familial hypercholesterolemia drug.
J02	Heart attack risk with COX-2 broadened to include most NSAIDs
M17	Superbug slain by soil antibiotic
M15	Aspirin may protect against gentamicin-induced hearing loss.
M09	Getting rid of the furanocoumarins in grapefruit juice abolishes the juice's effects on CYP3A drug metabolism
M01	Astellas acquires rights to two new orally-active prolyl hydroxylase inhibitor drugs to treat anemia.
A26	GI hormone oxyntomodulin lowers appetite, increases activity level
A26	FDA approves first generic pravastatin.
A25	University of Michigan to pay for preventive diabetes meds for its employees.
A21	Orally available iron chelating agent desafirox shows promising results.
A20	Roche files with FDA for approval of its anemia drug CERA (continuous erythropoetin receptor activator)
A19	FDA grants priority review to Neurochem for Fibrillex - AA amyloidosis drug.
A13	FDA announces public meeting focusing on regulation of nanotechnology
M21	Nabi to resume development of Staph. vaccine.
M17	New vitamin D anticancer effects may be separable from its bone effects.
M15	Six men in monoclonal antibody drug trial critically ill.
M12	Losartan metabolite activates PPAR-gamma
M09	Nabi's NicVax (smoking cessation vaccine) given fast-track status by US FDA.
M06	Annals: Dramatic recent rise in community-acquired MRSA infections.
M03	Serotonin may play a role in hardening of the arteries.
M02	Hyperglycemia and hypoglycemia associated with use of gatifloxacin.
F24	FDA approves new antifungal drug (Eraxis) effective against serious Candida infections.
F24	Tolvaptan receives FDA fast-track approval status to treat polycystic kidney disease.
F21	Is there a way to avoid the bladder toxicity of cyclophosphamide?
F21	Alginate-encapsulated pancreatic islet cell transplants for diabetes.
F13	Neurochem submits Fibrillex to the FDA for control of AA amyloidosis
F06	Synthetic heparin could replace animal-derived drug.
F01	Nabi announces fast tracking of hepatitis C immune globulin by the FDA to prevent HCV reinfection.
J28	Baxter mourns death of William Graham, pioneer and leader in healthcare.
J28	FDA approves first ever inhaled insulin for the treatment of diabetes.
J26	FDA approves Sutent - new angiostatin treatment for metastatic kidney or stomach cancer.
J26	Aprotinin (Trasylol) linked to increased risk of kidney failure, heart attack and stroke.
J24	Alagebrium (a collagen cross-link breaker) softens arteries - and that's good for you.
J24	Archives: Chronic warfarin use increases risk of bone fracture.
J23	Annals: Liver failure and hepatitis from telithromycin.
J22	AHA review casts doubt on cardiovascular health benefits of soy-based foods.
J21	British study shows that work stress linked to both heart disease and metabolic syndrome.
J21	Medicare Part D changeover leaves some Florida patients without payments for transport to dialysis.
J19	New drug label rule intended to reduce medical errors.
J19	Study of drug resistance among bacteria found in soil can potentially guide new drug development.
J19	Commonly used antidepressants may also affect the immune system.
J19	MMWR: Type A influenza highly resistant to amantadine derivatives
J18	Rockwell Medical Technologies gets rights to market vitamin- and carnitine-supplemented dialysate.
J17	Anti-obesity drug from cannabis really works?
J16	Canadian study suggests higher mortality among diabetics treated with sulfonylurea drugs vs. metformin.
J15	Acetazolamide reduces sleep apnea severity in heart failure patients.
J15	Hypothalamus has a fatty acid sensor that may regulate food intake
J07	CJASN: Diagnostic and Therapeutic Corner: HAART and the Kidney
J07	Brain protein (p11) may play a critical role in depression.
J06	Post-marketing data detects new onset / worsening of macular edema in patients taking Avandia (rosiglitazone).
J05	MRSA patterns in ICUs changing: 64% prevalence rate, hardier, bugs, but less multi-drug resistance.
J04	FDA approves conivaptan (Varprisol) for treatment of euvolemic hyponatremia in hospitalized patients.
J04	Adenosine receptor antagonist completes phase 2 trials for congestive heart failure.
D27	Acetaminophen can cause acute liver failure when usual dose is even slightly exceeded.
D26	Dalbavancin (a vancomycin-like drug) effective in mice against anthrax.
D17	Heteropolymer antibodies - a new approach to treat and prevent? MRSA infections.
D17	CDC recommends new blood test to diagnose TB infection.
D14	Amgen buys Abgenix, maker of panitumumab (colon cancer drug).
D12	Oral endothelial receptor antagonist ambrisentan effective in pulmonary HTN.
D11	Pramexipole for restless legs syndrome in nonuremics.
D10	Encyclopedia of traditional Indian medical knowledge to be on the internet.
D03	Random testing shows high lead levels in some imported Chinese plums.
N28	Higher dose of Fosrenol (lanthanum carbonate) approved by FDA for ESRD patients.
N17	Oralyn, an oral insulin-like drug, to be launched this month in Ecuador.
N17	Tea, cinnamon, buckwheat, and cherries for diabetics.
N17	AHA: CV mortality benefits of diuretics linked to alpha-adducin genotype.
N16	AHA: Aliskiren (renin inhibitor) adds to anti-HTN effects of irbesartan.
N12	Risk-stratified analysis proposed to analyze RCTs to detect harm.
N07	AAKP info sheets on Medicare Part D drug benefit for kidney patients.
N06	More on the new FDA digital drug label submission requirement.
N06	New FDA-supported website lists latest approved drug labels for all meds.
O30	Making sense of the new Medicare Part D drug plan.
O28	FDA delays decision on approving inhalable insulin
O27	New endogenous carbohydrate (INS2) discovered that lowers blood glucose.
O26	ASN Renal Week 2005 abstracts now available on-line.
O24	Shire highlights publication of 1 and 3-year Fosrenol extension study.
O20	Tigecycline may offer promise to treat MRSA and vancomycin-resistant bacteria.
O18	RPA compiles info on Medicare D drug benefit plan on its website.
O12	New defensin-class antibiotic isolated from pine forest fungus.
O05	Generic form of amlodipine approved by the FDA
S29	JASN: Acute phosphate nephropathy following certain bowel preps.
S28	Toprol (metoprolol)/Topamax/Tegretrol look-alike names prompt FDA alert letter.
S28	Nabi sues Ohio company for patent infringement over generic calcium acetate.
S26	Genzyme could see upside if Renagel included in Medicare Part D.
S25	Genes on chromosome 2 linked to resistant hypertension.
S22	Affymax launches phase 2 study of NESA to treat anemia in European CKD patients.
S22	Pharma organization launches global clinical trials database.
S21	Nabi launches study to see if StaphVax will protect dialysis patients long-term.
S20	Novartis oral renin inhibitor aliskiren shows good results in phase III trial.
S13	Pioglitzaone improves cardiovascular outcomes in diabetics.
S11	FDA approves first glitizar-class drug for treatment of type 2 diabetes.
S09	FDA advisory panel recommends approval of inhaled insulin.
A28	Medicate part D to help cover costs for kidney patient drugs.
A25	Ten Canadian pharmacies apply for license to sell Rx drugs in Nevada.
A22	Scios announces recommended use initiative for Natrecor.
A22	Long-acting form of exenatide works in type 2 DM; Amylin shares soar.
A19	Jury awards widow 253 million in Vioxx suit against Merck.
A19	Magnetic nanoparticle MRI used to visualize inflammed pancreas in type 1 DM.
A19	Myogen announces phase 2 trial results of darusentan in resistant hypertension.
A19	Novartis trying to develop alternative phosphate binding drug.
A18	Will FDA approve diabetes-related health claims for chromium picolinate?
A16	Do clinical trial docs leak info about new drugs to stock brokers?
A16	Analgesic drug use linked to high blood pressure in women.
A16	Kidney Drug Coverage website: Teleconference schedule
A11	Following clinical guidelines in elderly can lead to polypharmacy.
A11	Pfizer files for FDA approval of new renal cancer drug Sutent.
A02	Op-Ed piece suggests the FDA should loosen up; allow patient to choose some risk
J28	Drug dose adjustment in CKD: Guru texts may not agree.
J28	FDA bans use of Bayer fluoroquinolone in poultry to fight rise in superbugs.
J23	Is your clinical trial registered? If not, you may not get it published!
J22	Nabi initiates phase 1 trial of vaccine against another strain of S. aureus.
J22	Retinol-binding protein implicated in obesity, insulin resistance.
J19	Reductions in Medicare payments for IVIG lead to problems: Portent for EPO?
J19	Annals: If Medicare were to provide ACE-I for free, it would be cost effective.
J19	Natrecor (nesiritide) safety summary (Scios)
J14	NIH finds ethics violations by its employees in 44 cases.
J14	NEJM op-ed piece attacks continued use of nesiritide.
J14	New super-EPO (PT-401) drug under development.
J14	Genzyme on a roll - good financial results, drugs in the pipeline.
J13	Nabi says Staph vaccine ups immunity.
J11	Q-med gets funding to further develop Ixion's oxalate technology.
J11	Carotenoids give gold color to S. aureus, and protect it from oxidation by WBCs.
J08	Genomic mechanism of increased azathioprine toxicity identified.
J07	Phase 3 trial begins of endothelin A receptor antagonist in diabetic nephropathy
J06	House bill to mandate reporting of all pharma clinical trials in registry.
J06	Law introduced to help prevent counterfeit drugs, especially EPO.
J06	Growth hormone releasing factor may prevent malnutrition in stage IV CKD.
J04	Medlearn matters (SE0541) Medicare Prescription Drug Coverage
J30	Canadian Health Minister to restrict U.S. access to Canadian meds.
J29	Consumer reports announces "best buy" calciuim channel blockers.
J29	Keryx initiates phase 4 study of sulodexide to treat diabetic nephropathy.
J28	Pfizer review claims no link between Viagra use and blindness.
J27	Will a next-generation HBV vaccine be more effective? Trial in progress.
J27	Omiganan topical antibiotic designed to prevent central venous catheter infxns.
J24	Canada aims to curb internet drug trade.
J18	Acologix and Toray team up to commercialize uremic itching drug.
J14	Large multinational study shows restless legs syndrome common in nonuremics.
J04	Editorials, opinions (via Kaiser) on disclosing results of clinical trials.
J03	Kaiser electronic med system reduces medication errors in CKD patients.
M27	FDA investigating causes of blindness in users of Viagra/Cialis.
M26	Deep sea bacteria may provide new tools to kill MRSA.
M24	Crestor (rosuvastatin) associated with higher adverse event risk.
M20	Nabi ramping up large scale production of its Staph vaccine.
M19	New way of fighting antibiotic resistance - by blocking evolution in E. Coli.
M13	Naturally occurring nanovaults eyed as vehicles to deliver gene/tumor therapy.
M12	Neurochem to plead its case before the FDA for Fibrillex approval.
M09	Two studies document the rise of superbugs in the environment.
M05	Pollen, leaves from lilies cause acute renal and liver failure in cats.
M03	Consumer Reports website suggest Best Buys for ACE inhibitors.
M01	Sen. Frist explores idea of a ban on direct to consumer pharma advertising.
A27	Combo Vytorin (ezetimibe + simvastatin) lower CHO better than atorvastatin alone
A27	Indirect evidence that NSAIDS may prevent age-related macular degeneration.
A21	Shire to acquire Transkaryotic - gets into anemia market with DYNEPO.
A20	Nesiritide associated with an increased death rate in CHF patients.
A19	Neurochem announces preliminary results on Fibrillex for AA amyloidosis.
A18	Tougher CME conflict of interest rules take effect.
A18	Melbourne researchers develop safer and more effective "aspirin".
A13	Bugs in the gut could help doctors develop individualised healthcare
A07	Pfizer suspends sales of COX-2 inhibitor Bextra at the request of the FDA.
A07	FDA issues new rulings on NSAIDs - remove some, black box warnings for others.
A05	Genzyme launches phase 3 study of tolevamer to treat C. difficile
A01	Best buy recommends best value beta-blockers.
M21	Nesiritide associated with risk of reduced kidney function in CHF patients.
M18	Potential anti-prostate cancer effects of celecoxib.
M17	FDA approves Symlin to help manage diabetes.
M05	Pfizer working on new drug that raises HDL cholesterol.
M04	Curis issued patent for use of BMP-7 to treat CKD.
M02	FDA posts warning: Reduce starting dose of Crestor in Asians.
F21	Big three automakers launch e-prescribing initiative.
F17	Vitamin D may ward off prostate cancer.
F15	Teva announces US launch of recombinant growth hormone for short-stature kids.
F15	Hepatitis B vaccine administered orally via potatoes.
F15	US FDA to create an independent drug safety monitoring board.
F11	Meta chip provides quick, effective toxicity screen for new drugs
F11	Progress toward new remedy for chronic urinary tract infections.
F03	Another lanthanum-based phosphate binder in development.
F03	Microdosing used to study pharmacokinetics of new renin inhibitors.
J25	In retrospect, Vioxx may have caused many heart disease deaths.
J24	Amgen involved with new stem cell company, ViaCell, with IPO today.
J20	Merck threatens to cut off supply to Canadian pharmacies that sell to U.S.
J20	NEJM: Aspirin/esomeprazole better than clopidogrel for CV risk prevention.
J19	Amgen's next blockbuster drug - for osteoporosis.
J17	Data entry is top cause of medication errors.
J17	FDA requires handout be given to patients receiving amiodarone.
J17	Drfug reimportation faces new hurdles.
J15	FDA public meeting on COX-2 safety set for Feb 16-18
J15	FDA panel rejects OTC sale of statin drug made by Merck
J13	Advanced Magnetics initiates large-scale trial of ferumoxytol IV iron.
J11	Death in patient taking Crestor who had rhabdomyolysis.
J11	NIH implements royalty disclosure policy among its staff.
J10	NABI: Staph. aureus immune globulin treated patients leave hospital sooner.
J06	Pharmacy prescription errors increase at the start of each month.
J06	Canada considers shutting down internet drug trade.
J06	Publication bias in the news - leads to incorrect regulatory decisions.
J04	Long-term NSAID use linked to small intestinal damage, bleeding.
D28	Voriconazole gets FDA approval for treatment of Candidemia.
D23	FDA clears genetic test for cytochrome P450 variants involved in drug metabolism
D23	Teva pharma reacquires marketing rights to IV calcitriol in the U.S.
D22	Aspirin underused by people with diabetes.
D22	Pharma industry awaiting Michael Moore's new documentary film with trepidation.
D21	Nabi Pharma requests European regulatory approval for its StaphVAX product.
D21	Naproxen linked to increased risk of heart attack,stroke
D19	Consumer Reports: How to save money on buying statins.
D19	Consumer reports BEST BUY website now operational
D04	Gene identified that makes biofilm bacteria hibernate and evade antibiotics.
D02	Consumer Reports to launch BEST BUY prescription drug price comparison website.
N26	WHO warns of bird flu and possible upcoming flu pandemic.
N24	Carbonic anhydrase inhibition linked to retinitis pigmentosa
N10	Pfizer COX-2 inhibitor also doubles risk of heart complications
N07	U.S. FDA to focus more on safety of marketed drugs
N05	Mutant mushrooms trigger brain disease in Japanese dialysis patients
O24	New TB vaccine shown to be safe
O24	More on the Japanese dialysis patients with mushroom-associated illness
O22	Japanese CKD patients become ill after eating apparently non-poisonous mushrooms
O14	Nightline on ABC covers drug reimportation: video of Frist vs. Stabenow
O14	AAKP requests open formulary for kidney patients without restrictions
O10	Massachusetts e-health network to go live in 2005
O06	Bugs in the gut can influence the body's response to disease
O06	One in six chronically ill adults skips Rx due to cost
O05	Pyridostigmine effective in combatting orthostatic hypotension
O02	Miniature swimming robot might be used for drug delivery
S30	FDA comments on voluntary Vioxx withdrawal
S30	Merck recalls Vioxx (rofecoxib) worldwide over concerns of increased CV risk
S20	Progress made on drug trial registry
S20	New British Approved Names (BANs) for generic drugs
S12	Company making fake urine for research
A21	Vermont sues FDA over block of Canadian drug imports
A18	Illinois governor announces extensive prescription drug reimportation program
A17	Newspaper examines industry bias in reporting sponsored trial results
J26	Pharmacy benefit managers a growing force in Medicare
J13	New and old ways to get lead poisoning: dinner plates and Ayurvedic medicine
J07	Methotrexate use in dialysis patient may have led to patient's death
J28	NY Times investigates drug company payments for prescribing interferon for HCV
J25	U.S. consumer group argues that Crestor (rosuvastatin) is unsafe
M01	Medicare Prescription Drug Assistance Program website
M26	Packaging for Na/K too similar; needs to be differentiated
M20	Labeling similarity of Baxter sodium, potassium products questioned in Calgary
M20	Calgary pharmacy potassium-sodium mixup happened before
J09	Story on Genzyme and its plans for future products
N26	FDA labeling change for lovastatin re myopathy / liver function
N26	FDA labeling change for simvastatin re myopathy / rhabdomyolysis
O21	FDA medwatch safety labeling changes (incl. lisinopril, enoxaparin)
O19	US prescription drug system under attack
O17	AJM: Drug promotion, rather than study publication, influences usage patterns
J06	Astoundingly high levels of mercury found in whale organs
D04	Red wine consumption interferes with cyclosporin availability
O29	Corey Nahman Pharmacy News