HDCN Abstract:  ASN Annual Meeting 2020 -- Digital Meeting  

Chertow GM, Raggi P, Bellasi A, et al.

SNF472 Consistently Slows Progression of Coronary Artery Calcification Across Subgroups of Patients on Hemodialysis

ASN Annual Meeting 2020 -- Digital Meeting
J Am Soc Nephrol (Oct) 31:6A 2020

BACKGROUND

In the CaLIPSO study, SNF472 significantly attenuated progression of coronary artery calcium (CAC) volume score compared with placebo. This pre-specified analysis examined CAC progression in key subgroups.

METHODS

Patients were randomized to SNF472 300 mg (n=92), SNF472 600 mg (n=91) or placebo (n=91) infused 3x/week during hemodialysis (HD) for 52 weeks on top of standard care therapy determined by each investigator. We examined change in log CAC volume score from baseline to week 52 in the combined SNF472 dose groups vs placebo for subgroups of age, sex, diabetes, dialysis vintage, arteriosclerotic cardiovascular disease (ASCVD), use of non-Ca phosphate binders, Ca-based phosphate binders, calcimimetics, activated vitamin D, warfarin, or statins in the modified ITT population (mITT, defined as subjects who received at least one dose of study drug and had an evaluable post-baseline CT scan).

RESULTS

Baseline characteristics were similar across treatment groups: mean age was 64 y, 39% were female; 62% had diabetes, and 41% had prior ASCVD. Median HD vintage was 42 mo; 33% received HD for ≥5 years. Concomitant medications at baseline were: 62% non-Ca phosphate binders, 28% Ca-based phosphate binders, 31% calcimimetics, 51% activated vit D, 8% warfarin, and 64% statins. In the overall mITT, CAC volume progression was 11% in the combined SNF472 groups vs 20% in placebo (p=0.016). Treatment differences for CAC volume progression were similar across subgroups (Figure). All interaction p-values were non-significant and comparisons favored SNF472 vs placebo in each subgroup.

CONCLUSION

SNF472 treatment for 52 weeks attenuated CAC progression compared with placebo in all subgroups.

c Copyright 2020 -2021 American Society of Nephrology. Reproduced with permission.
All ASN abstracts from the 2020 Annual Meeting are available at this link and also are archived in .pdf form at ASN-Online.org

Disclaimer: Abstracts often have errors, both typographical and otherwise. This posting is an electronic translation of submitted abstracts which has not been verified against the original submitted abstract nor with the authors for accuracy. As a result, there may be errors, especially with regard to drug doses, but not limited to these. Abstracts undergo only limited review, and data often are changed as a result of the peer review process, so their reliability is less than manuscripts published in peer-reviewed journals. In using these summaries, you are agreeing that you are aware of these limitations.

The materials are provided on an as-is basis without any warranty of any kind, either express or implied. In addition to errors, the information presented may be incomplete or outdated. The information contained is not intended nor recommended as a substitute for professional medical advice. You are advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each device to be used or drug to be administered to verify the dosage, the method and duration of administration, or contraindications. It is the responsibility of the treating physician or other health care professional, relying on independent experience and knowledge of the patient, to determine drug, disease, and the best treatment for the patient.

To the fullest extent permitted by law, HDCN, ASN and their affiliates and suppliers disclaim all warranties, express or implied, including, but not limited to, any warranty of merchantability, non- infringement or fitness for a particular purpose.

In no event shall HDCN, ASN, or their affiliates or suppliers be liable for any damages whatsoever (including, but not limited to, direct, indirect, incidental, consequential, punitive or exemplary damages, or any damages for loss of profits, use, data, goodwill or other intangibles) arising from or in any way relating to these terms, the materials, or any information, goods or services obtained from or referred to in the materials, whether based on warranty, contract, tort (including, but not limited to, negligence), or any other legal theory, and whether or not any or all of the limited entities is advised of the possibility of such damages.