HDCN Abstract:  ASN Annual Meeting 2020 -- Digital Meeting  

Chertow GM, Raggi P, Bellasi A, et al.

SNF472 Consistently Slows Progression of Coronary Artery Calcification Across Subgroups of Patients on Hemodialysis

ASN Annual Meeting 2020 -- Digital Meeting
J Am Soc Nephrol (Oct) 31:6A 2020


In the CaLIPSO study, SNF472 significantly attenuated progression of coronary artery calcium (CAC) volume score compared with placebo. This pre-specified analysis examined CAC progression in key subgroups.


Patients were randomized to SNF472 300 mg (n=92), SNF472 600 mg (n=91) or placebo (n=91) infused 3x/week during hemodialysis (HD) for 52 weeks on top of standard care therapy determined by each investigator. We examined change in log CAC volume score from baseline to week 52 in the combined SNF472 dose groups vs placebo for subgroups of age, sex, diabetes, dialysis vintage, arteriosclerotic cardiovascular disease (ASCVD), use of non-Ca phosphate binders, Ca-based phosphate binders, calcimimetics, activated vitamin D, warfarin, or statins in the modified ITT population (mITT, defined as subjects who received at least one dose of study drug and had an evaluable post-baseline CT scan).


Baseline characteristics were similar across treatment groups: mean age was 64 y, 39% were female; 62% had diabetes, and 41% had prior ASCVD. Median HD vintage was 42 mo; 33% received HD for ≥5 years. Concomitant medications at baseline were: 62% non-Ca phosphate binders, 28% Ca-based phosphate binders, 31% calcimimetics, 51% activated vit D, 8% warfarin, and 64% statins. In the overall mITT, CAC volume progression was 11% in the combined SNF472 groups vs 20% in placebo (p=0.016). Treatment differences for CAC volume progression were similar across subgroups (Figure). All interaction p-values were non-significant and comparisons favored SNF472 vs placebo in each subgroup.


SNF472 treatment for 52 weeks attenuated CAC progression compared with placebo in all subgroups.

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