Bukoski RD, Nemeth EF, Rogers KV, Bian K
Modulation of resistance artery force generation by activation of an
extracellular calcium receptor in the perivascular nerve
network
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:125A 1996
RT-PCR was used to amplify a 1045 bp segment of the rat kidney
extracellular calcium receptor (CaR) from RNA isolated from aorta, superior
mesenteric artery, mesenteric resistance artery, dorsal root ganglion (DRG),
and kidney. CaR message was detected in kidney and DRG, but not in blood
vessels. CaR was detected by western blot of mesenteric resistance artery
and localized to the perivascular nerves by immunocytochemistry. Taken
together, this suggested CaR in perivascular sensory nerves, and a possible
role in mediating calcium-induced vasular relaxation; indeed, phenol
denervation ablated this response
Comment: Extracellular calcium receptors appear to be expressed in
sensory
nerves and localized in perivascular nerve endings where they mediate the
calcium-induced relaxation of isolated, preconstricted small arteries,
presumably by the release of a nerve-derived vasoactive substance.
This adds another complexity in the interpretation of calcium effects on
vascular tone and suggests a novel target for modulating microvascular
responses.
Jason G. Umans, M.D., University of Chicago
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11th Scientific Meeting, American Society of Hypertension
H: Pathophysiology :
Calcium
H: Pathophysiology :
Vascular pathology