fogari R, Corradi L, Poletti L, Zoppi A, Lusardi P, Malamani
GD
Sexual activity in hypertensive males treated with
lisinopril or atenolol: a cross-over study
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:151A 1996
Newly diagnosed non-diabetic hypertensive males, age 40-49, were
randomized to receive monotherapy with atenolol 100 mg or lisinopril
20 mg per day. Treatment was for 16 weeks, then the agents were
crossed over for another 16 weeks. There was a 4 week placebo washout
period at study onset and before crossover. Both agents had similar
efficacy, but sexual dysfunction as reported by a questionnaire was
greater with atenolol (17%) than with lisinopril (3%). Frequency of
intercourse fell at onset of treatment with either agent, but
recovered only with lisinopril.
Comment: Male sexual dysfunction (impotence, loss of libido, etc.) is
a common
complaint and may lead to non-compliance with treatment. This report
points to the non-specific but temporary effect of BP control itself,
and to the specific effects of beta blockade. One concern I had was
that atenolol was used at the upper limit of its useful dose range,
while the lisinopril was dosed in a mid-range level. One might expect
more adverse CNS and autonomic effects from atenolol at the 100 mg
level.
(James A. Sondheimer MD, Wayne State University, Detroit, MI)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
11th Scientific Meeting, American Society of Hypertension
H: Drug therapy :
ACE inhibitors
H: Drug therapy :
Beta blockers