Nielsen S, Dollerup J, Mogensen CE
Enalapril/HCTZ 20/6 mg reduces albuminuria in patients with
essential hypertension: an atenolol controlled 3 month study
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:158A 1996
Elevated urine albumin excretion (UAE) can be reduced by ACE
inhibitors in essential hypertension. 175 patients with EH, mean
age 51 +/- 9 yrs with normal serum creatinine without overt
proteinuria (Ualb/Cr < 20 mg/mmol) were enrolled in a doulbe-blind
12-week RCT comparing enalapril/hctz 20/6 mg and atenolol 50 mg
daily on blood pressure and UAE. Blood pressure was similarly
reduced but Ualb only decreased in the enalapril/hctz group. This
effect on Ualb was also seen in the normoalbuminuric (Ualb/Cr < 2
mg/mmol) subgroup. In conclusion, at these doses, the drugs had
similar effects on blood pressure, but only the ACE
inhibitor/diuretic combination decreased UAE.
Comment: This was a short-term study, but supports the accumulating
evidence
that inhibiting AII formation decreases proteinuria in hypertensive
patients. (David J. Leehey, M.D., Loyola University at Chicago)
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11th Scientific Meeting, American Society of Hypertension
H: Pathophysiology :
Kidney in hypertension
H: Drug therapy :
ACE inhibitors