Nielsen S, Dollerup J, Mogensen CE
Similar effects of 3 months treatment with losartan and
enalapril on albuminuria, blood glucose, and lipids in patients
with essential hypertension
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:158A 1996
The effects of AII antagonists vs. ACE inhibitors on renal and
metabolic parameters in essential hypertension (EH) have been
presumed to be similar. However, there are relatively few studies
addressing this point.
In a double-blind 12-week RCT, enalapril
(E) 20 mg/d was compared to losartan (L) 50 mg/d in 93 patients
with EH with normal renal function without overt proteinuria.
Blood pressure and Ualb/creat ratios were reduced similarly in both
groups. No differences in blood glucose or lipids were observed.
In conclusion, at these doses, the drugs had similar effects on
blood pressure, renal, and metabolic parameters.
Comment: This was a short-term study. It is unclear whether AII
antagonists
will have the same effects as ACE inhibitors in the long-term. The
answer to this question requires long-term controlled studies.
(David J. Leehey, M.D., Loyola University at Chicago)
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11th Scientific Meeting, American Society of Hypertension
H: Pathophysiology :
Kidney in hypertension
H: Drug therapy :
ACE inhibitors