Robinson K
Homocysteine and renal disease
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:185A 1996
The role of homocysteine in the causation of atherosclerosis and thrombosis
is increasingly being
appreciated. Dialysis patients have quite high levels, and it is logical to
attempt to normalize
them in some way if possible.
Robinson measured plasma homocysteine levels in 176 ESRD patients and normal
controls. Levels in
dialysis patients averaged 26 uM vs. 10 uM in controls. Dialysis patients
with levels in the upper
2 quintiles had a 2.9 relative risk of vascular disease.
Comment: Very promising is the possibility that, by giving industrial
doses of folate to
dialysis patients, elevated plasma homocysteine levels may be lowered into
the near normal range.
Also, when high flux dialyzers are used, plasma folate removal may be
accelerated, requiring
increased supplementation. (John T. Daugirdas, M.D., University of
Illinois at Chicago)
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11th Scientific Meeting, American Society of Hypertension
H: Non drug therapy :
Dietary/electrolyte therapy
CRF by organ system :
Nutrition