Sudhir K, Esler M, Jennings GL, Funder JW, Komesaroff PA
Estrogen supplementation attenuates vasoconstrictor responses
to norepinephrine and decreases total body norepinephrine
spillover in perimenopausal women
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:6A 1996
Total body and forearm NE spillover and forearm blood flow were
measured in 12 perimenopausal women before and during 8wk estrogen
supplementation (n=7) or placebo treatment (n=5). Estrogen, but not
placebo, decreased BP (127/81 to 114/71), attenuated dose- dependent
NE-induced forearm vasoconstriction, and decreased total body (but not
forearm) NE spillover.
Comment: In this small study, subacute estrogen replacement appeared
to have
marked effects on BP within a normal range that correlated with effects on
NE spillover and effect. This provocative study suggests one possible
mechanisms of estrogen effect and should be extended to other vasopressor
pathways and to larger populations, including hypertensives and women on
chronic estrogen replacement.
Jason G. Umans, M.D., University of Chicago
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11th Scientific Meeting, American Society of Hypertension
H: Special problems :
Women
H: Pathophysiology :
Sympathetic nervous system