Tinucci T, Abrahao SB, Marcondes M, Mion D Jr
Mild renal insufficiency increases sympathetic nerve
activity in humans
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:46A 1996
A body of data indicates that the sympathetic nerve activity is
increased in subjects with end stage renal failure on hemodialysis. No
information sympathetic nerve activity is available in subjects with
mild renal insufficiency.
These authors studied peroneal nerve microneurographic
recordings in 8 patients with renal insufficiency (creatinine 1.9
mg/dl to 5.8 mg/dl), 8 hypertensives and 8 normotensive subjects.
Plasma renin activity was also measured in all study participants. The
authors found that nerve activity was similar for the groups with
renal disease and those with essential hypertension but higher than
normotensive subjects. They also found a positive correlation of nerve
activity with serum creatinine and plasma renin activity. No mention
was made of any relationship with blood pressure.
Comment: These findings are very preliminary and age and
concomitant antihypertensive therapy must be considered in such work.
A larger study would certainly be worth undertaking. George
Mansoor, M.D., University of Connecticut
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11th Scientific Meeting, American Society of Hypertension
H: Pathophysiology :
Sympathetic nervous system
H: Pathophysiology :
Kidney in hypertension