Weir MR, Saunders E
Racial similarity in response to the angiotensin converting
enzyme inhibitor trandolapril
11th Scientific Meeting, American Society of Hypertension
Am J Hypert
(Apr) 9:174A 1996
Blacks have been found to have reduced responses to certain blood pressure
lowering agents compared with whites (Moser M, J Natl Med Assoc 87 Supple 8:
612, 1995). This effect has been noted for beta-blockers and ACE inhibitors,
particularly for older populations. The angiotensin II receptor blocker
losartan
is also slightly less effective in blacks compared with whites (Goldberg A,
Sweet C, Can J Cardiol 11 Suppl F:27F, 1995). This differential response is
not
seen when small doses of diuretics are added to the regimen.
In this study hypertensives were treated with the ACE inhibitor trandolapril
for 6 weeks. There was no difference in response in 505 non-black subjects
compared with 322 black subjects. Therefore, at least for this ACE inhibitor
there are no important racial differences in responsiveness.
(Mark S. Paller, M.D., University of Minnesota, Minneapolis)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
11th Scientific Meeting, American Society of Hypertension
H: Drug therapy :
ACE inhibitors
H: Special problems :
Ethnic populations