van der Kleij FGH, Navis GJ, Scheffer H, de Zeeuw D, de Jong PE
ACE gene polymorphism does not determine short term renal response to ACE inhibition in proteinuric patients
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Sep) 7:1326 1996

In non-diabetic patients, the ACE deletion (DD) genotype is associated with an increased rate of renal functional loss. ACE inhibition may not be effective in preserving renal function in these patients. The short-term response (4-12 wks) of U prot, MAP, GFR, and ERPF to ACE inhibitors was determined in DD, ID, and II genotype patients. During ACE inhibitor therapy, Uprot, MAP, and GFR fell and ERPF rose significantly in all groups. Changes for all parameters were similar for all groups. The reason for the increased rate of renal functional loss in DD patients is unclear and cannot be predicted by the effect of ACE inhibitors on these parameters.

Comment: These data appear to conflict with the data of Kawamura et al. (abstract 377). However, it should be noted that this was a short-term study. Effects of ACE inhibitors in non-diabetic DD patients may be different in the long-term than in the short-term. (David J. Leehey, M.D., Loyola University at Chicago)

To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
CRF by problem area : Progression

---

---