Pai P, Hindell P, Stevenson A, Mason H, Bell GM
Human genotypic polymorphisms and susceptibility to hydrocarbon
(HC)- assocaited glomerulonephritis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1340 1996
Hydrocarbons and solvents are known to cause acute renal failure.
Acute tubular necrosis has been reported following accidental,
occupational and medicinal exposure. Abusive sniffing of volatile
organic solvents may also cause renal failure. The glomerular effects
of hydrocarbons have not been well established or characterized.
These authors tested the hypothesis that genetic variations in
metabolic enzymes influence susceptibility to hydrocarbon induced
glomerulopathy. They measured hydrocarbon exposure by questionnaire
and genotypic polymorphism of cytochrome P450 2D6, glutathione S-
transferase Mu and Theta, and N-acetyl-transferase in 41 patients with
biopsy proven glomerulonephritis. Patients with glomerulonephritis
had more exposure to hydrocarbons by questionnaire than did a control
group of 60 healthy controls. There were no genotypic differences
between patients and controls. There were some differences in
glutathione S- transferase Mu and N-acetyl-transferase genotypes in
patients with membranous nephropathy compared to controls.
Comment: This intriguing study shows an association between
chronic glomerular pathology and exposure to hydrocarbons. The study
design does not allow the conclusion that the relationship is causal
nor is there support of the hypothesis that the measured genetic
polymorphisms are related in any way to increased susceptibility.
There remains little evidence of specific glomerular injury from
chronic hydrocarbon exposure.
(George R. Aronoff, M.D., University of Louisville, Kentucky)
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Am Soc Nephrol
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Proteinuria/Hematuria :
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