Venkata Seshan S, Barisoni L, Smith S, Needle M, D'Agati V,
Appel GB
Renal disease in anti-phospholipid antibody syndrome (APLS)
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1343 1996
Seshan et al reviewed the clinical course and renal biopsies of 26 patients
with anti-phospholipid antibodies, excluding those with SLE. Sixty-five
percent of patients had evidence of extra-renal thromboses, and the mean
serum creatinine was 2.0 with mean urine protein of 4.4 gm/day with almost
half of the patients being nephrotic.
Findings on renal biopsy included
thrombotic microangiopathy, with or without "lupus like nephritis" usually
consisting of membranous GN and nonspecific arteriosclerosis. Patients
were treated with anticoagulation and/or immunosuppression. Follow-up
based on treatment was not given; however, one patient developed SLE, three
developed ESRD and 11 of 24 patients had improved renal function.
Anticoagulation and/or immunosuppression have been used for treatment and
while most of the patients did show improvement, it is unclear what role
these forms of therapy played.
(N. Kevin Krane, M.D., Tulane University)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
Proteinuria/Hematuria :
Lupus nephritis