Conlon PJ, Athirakul K, Kovalik E, Schwab SJ, Crowley J,
Stack R, Albers F
Long term follow up of asymptomatic renal vascular disease
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1384 1996
There is continued interest in searching for additional predictors of CV
mortality.
1200 patients who had cardiac catheterizations also had abdominal flush
aortograms done. 15% of these cases had 50% or greater renal
artery stenosis (RAS) on one or both sides. The 4 year mortality of this
group was near 20% higher than the group without RAS. RAS was an
independently predictive factor of mortality using a Cox proportional
hazards model. Other factors predictive of mortality were: increased age,
diabetes, HBP, CHF and decreased ejection fraction. Most deaths (70%) in
both groups were cardiovascular deaths.
Comment: RAS in this study appeared to be a marker of a more
advanced
state of atherosclerotic vascular disease. It would have been helpful
to know the results of the coronary angiograms, but such information was
not provided, therefore the possible parallel between coronary and renal
AS and CV mortality will remain suspected but not proven.
(Jose Ganel, M.D., University of California Davis at Sacramento,
CA)
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Am Soc Nephrol
H: Special problems :
Renovascular hypertension
H: Pathophysiology :
Vascular pathology