Posthuma N, ter Wee PT, Donker AJM, Oe LP, Verbrugh HA, Van
Dorp W, Sayers J, Peers E
Long-term improvement in ultrafiltration in CCPD patients using
icodextrin for the long daytime dwell
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1433 1996
The authors report preliminary data of a prospective randomized trial with
polyglucose (Icodextrin) versus dextrose solutions used for the long
daytime dwell in patients undergoing CCPD. Of the 38 patients who
entered the study, 29 had completed 6 months or more by April 1996,
(16I, 13D). 7 patients had completed 24 months (3I, 4D). Use of icodextrin
inclreased daytime UF by about 300 ml, and this increase was maintained up
to 24 months, providing an opportunity for reduced fluid restrictions with
improved dialysis and clearances.
Comment: This ongoing study confirms previous reports demonstrating
the advantage of polyglucose over conventional dextrose, to maintain
ultrafiltration during the long dwell. However no precise results are
provided so that it is quite impossible from the data available in the
abstract to have an estimation of the real differences between the two
solutions. It is interesting to note that the effect of polyglucose seems
stable during a long period (up to two years in the abstract).
(Christian Verger MD, Pontoise, France)
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