Brunet P, Saingra Y, Dussol B, Loenetti F, et al
Predictive value of inflammatory markers in hemodialysis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1440 1996
In 1993 these investigators measured the inflammatory markers C-reactive
protein, alpha 1 acid glycoprotein, and fibrinogen in the serum of 101
hemodialysis patients on a single occasion. Subsequent mortality was not
associated with levels of any of these markers but was highly correlated
with serum albumin concentration. These finding contrast sharply with a
report last year at these meetings by Bergstrom et al., who showed that
inflammatory markers correlated better than albumin with mortality and with
findings by Kaysen et al., who showed a strong correlation between
inflammatory markers and serum albumin (see Kaysen, p 1486).
Comment: Causes of morbidity and mortality may differ among
populations of ESRD patients. It is of interest that age did not correlate
with mortality in these investigators' patients (p = 0.56), suggesting that
an unusual and perhaps non-inflammatory cause predominated. In addition,
the single measurement of inflammatory markers may be less sensitive as a
predictor of mortality than the serial measurements of albumin and
C-reactive protein reported by Bergstrom.
(Thomas A. Depner, M.D., University of California at Davis)
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Am Soc Nephrol
CRF: Problem Areas :
Outcomes (Morbidity, Mortality)
CRF by organ system :
Nutrition