Flynn JT, Kershaw DB< Parekh RS, Sedman AB, Smoyer WE,
Valentini RP, Bunchman TE
Treatment of children with severe Henoch-Schonlein purpura
related nephrotic syndrome with oral cyclophosphamide induces
remission of nephrotic syndrome
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1772 1996
The pediatric nephrology group from the University of Michigan performed a
retrospective review of the treatment of six patients ranging in age
between 5 and 15, presenting with severe Henoch-Schonlein Purpura who were
treated with oral cyclophosphamide. One patient had focal proliferative
GN, the remaining had crescentic GN.
Renal function was normal in 5 of 6
patients at presentation and renal function remained normal in all patients
at follow up, 7 to 42 months after diagnosis. There was a statistically
significant fall in the protein:creatinine ratio and a rise in serum
albumin.
Comment: The authors felt that stability of renal function was
significant because crescentic changes were present in 5 pts, and despite
this renal function did not deteriorate. However, no
conclusion regarding this form of therapy can be drawn until larger numbers
of patients are studied.
(N. Kevin Krane, M.D., Tulane University)
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Am Soc Nephrol
Proteinuria/Hematuria :
Henoch-Schoenlein Purpura