Franssen CFM, Stegeman CA, Ooost-Kort WW, Kallenberg CGM,
Cohen Tervaert JW
Prognostic factors in anti-myeloperoxidase associated
glomerulonephritis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1772 1996
Franssen et al tried to determine if outcome in 18 patients with
anti-myeloperoxidase associated GN could be predicted based on persistent
hematuria, nasal carriage S. Aureus, or cumulative
prednisone/cyclophosphamide dose in the first year. None of these factors
were predictive of patients who were likely to develop progressive renal
insufficiency. However, progressive renal insufficiency was associated
with detectable anti-MPO antibodies in 9 of 10 patients, while only 3 of 8
patients who did not have relapses or progressive renal insufficiency had
detectable anti-MPO levels.
Comment: The authors conclude that persistently high
anti-MPO levels are predictive of clinical course, however inadequate data
are given to suggest the most effective form of therapy.
(N. Kevin Krane, M.D., Tulane University)
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Am Soc Nephrol
ARF etiology :
Acute glomerulonephritis/RPGN
Proteinuria/Hematuria :
Vasculitis (Wegener's PAN, etc.)