Fliser D, Franek E, Fode P, Stefanski A, Lyons M, Ritz E
Acute infusion of non-hypercalcemic doses of PTH causes blood
pressure elevation
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1813 1996
The authors cite a study (Kidney Int 1993: 43: 700) that correlated
PTH levels, platelet intracellular Ca concentrations (PI Ca), and blood
pressure in patients with renal failure. They, therefore, examined the
effects of an acute infusion of human 1-34 PTH on blood pressure, muscle
blood flow, and PI Ca in normal human volunteers. The 10 subjects received
in random order either sham infusions or infusions of 200 units of
PTH.
The ionized Ca increased significantly with the PTH infusion (from 1.26 to
1.33 mmol/l) as did the PI Ca (from 49.9 to 52.8 nmol/l). The mean
arterial pressure increased from 84 to 88 mmHg. The changes in PI Ca
correlated with the changes in mean arterial pressure. Muscle blood flow
was not affected by the PTH infusion.
Comment: The duration of the infusion was not given. The changes
are modest and of unclear clinical significance. It would be interesting
to study a third group that receives the PTH infusion while taking a Ca
channel blocker such as verapamil. (James A. Delmez, M.D., Washington
University, St. Louis)
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Am Soc Nephrol
H: Pathophysiology :
Hormonal aberrations
CRF by organ system :
Cardiovascular/Hypertension