Slatopolsky E, Zhong M, Finch J, Denda M, Morrissey J, Brown
A
Is PTH gene expression increased in renal failure?
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Sep) 7:1818 1996
It is generally agreed that there is an increased PTH mRNA to b-actin or
GAPDH mRNA ratio in parathyroid glands or parathyroid-thyroid gland
complexes in uremic rats. Using 3 independent assay methods, the authors
found no significant increase in PTH/b-actin mRNA in the parathyroid glands
of uremic rats but was increased when assaying parathyroid and thyroid
tissue. They conclude that the increases in PTH in CRF are not due to
increased PTH gene expression but rather an increase in parathyroid cell
number and, perhaps, the rate of PTH secretion per cell.
Comment: This is a controversial study that, if correct, will
require a revision of our current concepts of the pathogenesis of
hyperparathyroidism in renal failure. (James A. Delmez, M.D.,
Washington University, St. Louis)
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Am Soc Nephrol
CRF by problem area :
Bone disease/aluminum