Suliman ME, Qureshi AR, Anderstam B, Gutierrez A, Lindholm B,
Bergstrom J
Nutritional status and plasms total homocysteine in
hemodialysis patients
23rd ESAO Congress, Warsaw
Int J Artif Organs
(Sep) 10:507 1996
It is now recognized that plasma homocysteine levels, which are known
to increase risk of atherosclerosis and thrombosis in non-dialysis
patients, are quite elevated in ESRD. In this abstract, Bergstrom's
group studied plasma homocysteine and cysteine levels in 117 HD
patients who were also evaluated re their nutritional status (65/117
were found to be malnourished).
The HD patients all had about
3-fold elevations of their homocysteine levels. Interestingly, plasma
homocysteine levels were lower (mean 24 uM) in malnourished HD
patients than in well nourished HD patients (mean 31 uM, normal
controls 9 uM). The malnourished HD patients had a higher incidence
of cardiovascular diseases despite their lower plasma homocysteine
levels.
Comment: The interesting result of this study
was, that in HD patients high plasma homocysteine levels did not
predict cardiovascular disease, and that cardiovascular disease
appeared to occur more commonly in malnourished patients. This is
similar to observations made by Foley et al at
last year's ASN (1995). Thus, nutritional status and plasma
homocysteine levels appear to be correlated in ESRD, but to have
opposite effects on cardiovascular disease. (John T. Daugirdas,
M.D., University of Illinois at Chicago)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
23rd ESAO Congress, Warsaw
CRF by organ system :
Nutrition
CRF by organ system :
Cardiovascular/Hypertension