Castelano M, Muiesan ML, Beschi M, Rizzoni D, Pasini G,
Salvetti M, Cinelli A, et al.
ACE insertion/deletion polymorphism is associated with
carotid artery intima-media thickness, but not left ventricular
mass, in a general population
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
The I/D polymorphism in ACE has been associated with increased
cardiovascular risk, presumably through increased local production of
Ang II and its effects on vascular growth. This study examined carotid
wall thickness and LV mass in 216 normal subjects; LV mass was not
dependent on genotype but carotid intima-medial thickness was, being
about 0.77 mm with the DD genotype, and 0.72 and 0.69 with the
ID and II genotypes, respectively. These findings were consistent
with an effect of local ACE on vascular growth.
Comment: It would have been of interest to see whether
the relationships held in essential hypertension, i.e., if both LVH
and carotid wall thickness are dependent on ACE genotype when there is
another stimulus - ie elevated blood pressure (Alan Jardine, M.D.,
Glasgow University, Scotland).
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16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Genetics
H: Exam and lab tests :
Tests for early atherosclerosis