Ferri C, Bellini C, Desideri G, Di Francesco L, Baldoncini R,
Carlomagno A, De Siati L, Santucci A
Endothelial dysfunction in human salt-sensitive
hypertension
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Family histories of cardiovascular accidents and hyperlipidemia
are more frequent in salt-sensitive (S) hypertensives than in
salt-resistant (R) ones. This study compares plasma endothelin-1
(ET-1) and von Willebrand factor levels, two markers of endothelial
damage, in S and R patients (n=20). Plasma ET-1 was also evaluated
during an oral glucose tolerance test (75 g) and angiotensin II
infusion (3.0 ng/kg/min for 60 min). No patient had hypertensive
complications at the time of the study.
Plasma and urine ET-1 and plasma Won Willebrand factor levels were
higher in
Salt-Sensitive than in Salt-Resistant hypertensives. Abnormal plasma ET-1 and
insulin
increments after oral glucose load were present in Salt sensitive
patients. Thus, despite the absence of clinical signs of overt
vascular damage, Salt sensitive hypertension is associated with an
early activation of markers of endothelial damage (Carmine
Zoccali, M.D, Reggio Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Salt (sodium, chloride) sensitivity
H: Pathophysiology :
Endothelium, Nitric Oxide