Ferro C, Haynes W, Webb D
Neutral endopeptidase inhibitors cause vasoconstriction in man
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Thiorphan, a neutral endopeptidase (NEP) inhibitor, caused
vasoconstriction in the forearm as assesed by plethysmography in
normal subjects. This action was not attenuated by enalapril. Another
NEP inhibitor had a simlar vasoconstrictive effect.
Comment: NEP degrades ANP and NEP inhibitors raise ANP
and were briefly seen as potential antihypertensive agents. This study
demonstrates that they can have the opposite effect, probably by
inhibiting degradation of endothelin but not Ang II which are also
degraded by NEP. The effects of these agents probably depends on
prevailing levels of Ang II, endothelin and other regulatory
influences eg sodium and volume status. If the patient is salt and
volume loaded to suppress the renin-angiotensin system, and ET, these
agents may increase ANP they reduce BP; otherwise they may
paradoxically increase the blood pressure. (Alan Jardine, M.D.,
Glasgow University, Scotland).
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16th Scientific Meeting of the International Society of Hypertension
H: Drug therapy :
ACE inhibitors