Halimi JM, Ribstein J, DuCailar G, Mimran A
Vitamin C induced recovery of the renal vasodilatory
response to l-arginine in essential hypertension
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
In essential hypertensives (EH), the renal vasodilatory response to
LA is markedly blunted, together with a lack of increase in urinary
cGMP and despite a rise in urinary excretion of NO2-NO3. Ascorbic
acid, a compound with antioxidant properties, is decreased in the
serum of EH. The response of effective renal plasma flow (ERPF,
urinary clearance of orthoiodohippuran) and urinary cGMP to L-Arginine
(30 g within 1 h) was assessed in age- and sex-matched normotensive
subjects (NT) and EH patients with or without coadministration of
ascorbic acid (2 g IV).
Ascorbic acid restored the cGMP increase
induced by L-arg and partially corrected the blunted renal
vasodilatory response to L-Arg observed in EH. Since in previous
studies, the abnormality found in EH was associated with changes in
cGMP and urinary NO2-NO3 suggestive of excessive degradation of NO, it
is possible that ascorbic acid exerts a protective effect against this
degradation through its antioxidant properties (Carmine Zoccali,
M.D, Reggio Calabria, Italy).
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Kidney in hypertension
H: Pathophysiology :
Endothelium, Nitric Oxide