Harrap S
General comments on genetic association studies in hypertension
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
The simplicity of identifying genetic markers by PCR has led to a
rapid increase in the number of reported genetic association studies
of candidate genes and disease. The reports at the ISH on the
renin-angiotensin system, ET and NOS illustrate many of the important
aspects about this type of study that are evolving.
1. A genetic marker needs to have physiological significance (eg
Ueda); fishing expeditions with non-functional polymorphisms will be
unsuccessful except in linkage studies when for example thousands of
markers are analyzed.
2. Large sample sizes are required to avoid type II error and the
sample size needs to be much larger when multiple comparisons are
made.
3. The population should be racially homogeneous. Otherwise, many of
the studies performed are meaningless and are little more than tastes
of what might be - were an adequately powered study performed
(Alan Jardine, M.D., Glasgow University, Scotland).
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16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Genetics