Kato J, Washimine K, Kitamura K, Eto T
Plasma proadrenomedullin N-terminal 20 peptide in patients with
hypertension and renal failure
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Proadrenomedullin N-terminal 20 peptide (PAMP) is a novel hypotensive
peptide found in N-terminal portion of the precursor of adrenomedullin
(AM). The authors measured the plasma concentrations of PAMP as well
as AM in patients with essential hypertension (EHT), primary
aldosteronism (PA) or chronic renal failure (CRF) and in a group of
normotensive controls. In addition, immunoreactive PAMP in plasma were
analyzed by reverse phase high performance liquid chromatography
(RP-HPLC).
The plasma PAMP concentration in the control subjects averaged 0.86
fmol/ml corresponding to 13% of that of plasma AM. The mean plasma
PAMP in patients with EHT (1.07 fmol/ml), PA (1.28) or CRF (1.39) was
significantly (P < 0.01) higher than that in the controls with a
significant correlation between plasma PAMP and AM levels.
PAMP is circulating in blood of the patients with EHT, PA and CRF as
well as the healthy subject. The increase of plasma PAMP in these
patients suggests a possible role of this novel hypotensive peptide
processed from proAM in regulating blood pressure in hypertension and
renal failure along with AM (Carmine Zoccali, M.D, Reggio
Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Special problems :
Endocrine hypertension