Matsumoto A, Hirata Y, Kakoki M, Nagata D, Momomura S,
Sugimoto T, Tagawa H, Omata M
Endogenous nitric oxide production in patients with chronic
renal failure
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
It is still controversial whether nitric oxide (NO) production is
increased or decreased in patients with renal failure. In this study
the production of endogenous NO was estimated by determining the NO
output in exhaled air (using an ozone chemiluminescence analyzer) in 40
patients
with chronic renal failure (CRF) on chronic hemodialysis and in 15
healthy controls. The NO output was calculated by multiplying the NO
concentration in the exhaled air by the minute ventilation (exhaled NO
output reflects instantaneous endogenous NO production, whereas
plasma NO2-/NO-3 concentration reflects NO synthesis on a longer time
scale).
Patients with CRF showed a higher NO concentration, a
greater NO output, and a higher plasma level of NO2-/NO3-
than controls. The plasma concentrations of NO2-/NO3-
significantly decreased after hemodialysis for 4 hours, while the
exhaled NO did not change.
In summary NO production is raised in
patients with CRF and it is uneffected by hemodialysis (which removes
NO2-/NO3-). Thus this study which applies a novel approach for
estimating NO production in dialysis patients fails to confirm
previous studies (based on in vitro measurements) suggesting that NO
production is increased during hemodialysis (Carmine Zoccali, M.D,
Reggio Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
CRF by organ system :
Cardiovascular/Hypertension