Mead LA, Wang NY, Klag MJ
A prospective study of coffee intake and hypertension: The
Johns Hopkins Precursors Study
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Withdrawal studies have shown that cessation of coffee intake lowers blood
pressure (BP) in established hypertension. This study estimates the
risk of hypertension associated with coffee intake in a cohort of
1,017 white male former medical students in classes 1948-. Coffee
drinking was assessed at baseline (mean age 26 yrs) and up to 10 times
over follow-up through 1992. Blood pressure was measured in medical
school and yearly by questionnaire after graduation. Median follow-up
was 32 years and response averaged 90% in every 5 year period.
Incidence of hypertension (N = 251) was positively associated with
coffee intake at baseline (p < 0.04) and over follow-up (p <
0.0001). For baseline intake, the Kaplan-Meier incidence of
hypertension by age 60 was 19% for nondrinkers, 28% for 1-, 31% for
3-, and 25% for 3-5 cups/day. Using a proportional hazards analysis, the
relative risk (RR) and 95% confidence interval (95% CI) of developing
hypertension associated with time-dependent coffee intake (as a
categorical variable) compared to nondrinkers was 2.6 (1.6-.1) for 1-,
3.2 (2.0-.1) for 3-, and 3.3 (2.0, 5.4) for 3 5 cups/day. After
adjustment for baseline blood pressure, and time-dependent number of
cigarettes/day and body mass index, results were unchanged.
Comment: These
findings emphasize the potential importance of coffee drinking in the
etiology of hypertension (Carmine Zoccali, M.D, Reggio Calabria,
Italy).
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
16th Scientific Meeting of the International Society of Hypertension
H: Special problems :
Smoking, ethanol, substance abuse